controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (hpmc) as the matrix former. the effects of the viscosity grades of hpmc and hpmc/lactose ratio and ethylcellulose (ec)/sodium carboxymethylcellulose (nacmc) and their concentrations on the release behavior of phenobarbital from hpmc matrices were invest...

microparticles offer various significant advantages as drug delivery systems, including: (i) an effective protection of the encapsulated active agent against (e.g. enzymatic) degradation, (ii) the possibility to accurately control the release rate of the incorporated drug over periods of hours to months, (iii) an easy administration (compared to alternative parenteral controlled release dosage ...

thymol, an important and advantageous component of many essential oils, has been applied as an antimicrobial agent in animals. to increase the duration of action of this compound in ruminants, it was decided here to prepare a controlled release carrier for thymol. hydroxy propyl methyl cellulose (hpmc) and ethyl cellulose (ec) were used as the matrix polymer here. mixtures of thymol with eight ...

triptoreline is a potent agonist of luteinizing hormone-releasing hormone, currently used in the treatment of prostatic cancer where therapy may be required over months or years. frequent injection of drug decreases patients’ compliance. the present study describes the formulation of a sustained release microparticulate drug delivery system containing triptoreline acetate, using poly (d,l lacti...

in the present study, floating drug delivery beads (fdds) were prepared with sodium alginate/ starch blend as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride solution as a hardening agent. in order to prepare the beads with different porosity and morphology the ratio between pore forming agent to polymer blend and ratio of the consti...

objective: in dental treatments, use of carriers for targeted antibiotic delivery would be optimal to efficiently decrease microbial count. in this study, gentamicin was loaded into polylactic co-glycolic acid (plga) microspheres and its release pattern was evaluated for 20 days.   methods: in this experimental study, plga microspheres loaded with gentamycin were produced by the w/o/w method. t...

objective(s):despite of wide range applications of polymeric nanoparticles in protein delivery, there are some problems for the field of protein entrapment, initial burst and controlled release profile.   materials and methods: in this study, we investigated the influence of some changes in plga nanoparticles formulation to improve the initial and controlled release profile. selected parameters ...

diclofenac sodium as ophthalmic dosage form is used in patients treatment of eye pain, swelling and redness recovering from cataract surgery but it faces the bioavailability limitation of eye drops due to effective protective mechanisms and corneal barrier functions in the eyes. therefore, this investigation was aimed to develop ocular film formulations to achieve controlled drug release. drug ...

acrylic-type polymeric systems having degradable ester bonds linked to ibuprofen were synthesized and evaluated as materials for drug delivery. ibuprofen, as a non-steroidal anti-inflammatory drug, was linked to 2-hydroxyethyl methacrylate by activated ester methodology in one-pot procedure. the resulting methacrylic derivative of ibuprofen was copolymerized with 2-hydroxyethyl methacrylate and...

introduction: tuberculosis (tb), with different types of respiratory tract involvements, has a high rate of mortality all around the world. endobronchial involvement, which is a slightly common tuberculous infection, requires special attention due to its severe complications such as bronchostenosis. aim of study of this study was describes, one type of pulmonary tuberculosis with less diagnosed...