objective: in the present study, the effects of aqueous saffron extract (crocus sativus l.) on the acquisition and reinstatement of morphine-induced conditioned place preference (cpp) in mice were investigated. materials and methods: subcutaneous administration of morphine (40 mg/kg for four days) produced place preference. intraperitoneal administration of aqueous extract (40 and 80 mg/kg for ...

Objective: In the present study, the effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) in mice were investigated. Materials and Methods: Subcutaneous administration of morphine (40 mg/kg for four days) produced place preference. Intraperitoneal administration of aqueous extract (40 and 80 mg/kg for...

Objective: It has been shown that berberine, a major component of Berberis vulgaris extract, modulates the activity of several neurotransmitter systems including dopamine (Da) and N-methyl-D-aspartate (NMDA) contributing to rewarding and reinforcing effects of morphine. Drug craving and relapsing even after a long time of abstinence therapy are the most important problems of addiction. In the p...

background it has been elucidated that berberis vulgaris (barberry) can alleviate morphine withdrawal syndrome. also it has been reported that aqueous extract of barberry possibly have inhibitory effect on nmda receptors. objectives in this study, we decided to evaluate the effects of aqueous extract of b. vulgaris fruit on morphine tendency in mice using conditioned place preference (cpp) meth...

objective: it has been shown that berberine, a major component of berberis vulgaris extract, modulates the activity of several neurotransmitter systems including dopamine (da) and n-methyl-d-aspartate (nmda) contributing to rewarding and reinforcing effects of morphine. drug craving and relapsing even after a long time of abstinence therapy are the most important problems of addiction. in the p...

background: role of nitric oxide (no) in morphine-induced conditioned place preference (cpp) has already been proposed in the rat medial septum (ms), but no molecular evidence has been provided to clear this fact. methods: effects of intraseptal injections of l-arginine and/or ng-nitro-l-arginine methyl ester (l-name) on morphine place conditioning in wistar rats were examined. morphine (2.5-7....

In the present study, the effects of intra-cerebral hippocampus (CA1) injections of apomorphine D1, D2-like receptors agonists on morphine-induced place preference in male Wistar rats have been investigated. Subcutaneous administration of different dose of morphine sulphate (1, 3, 6 and 9 mg/kg) produced a dose-dependent conditioned place preference (CPP). Intra-cerebral hippocampus (CA1) admin...

In the present study, the effects of intra-cerebral hippocampus (CA1) injections of apomorphine D1, D2-like receptors agonists on morphine-induced place preference in male Wistar rats have been investigated. Subcutaneous administration of different dose of morphine sulphate (1, 3, 6 and 9 mg/kg) produced a dose-dependent conditioned place preference (CPP). Intra-cerebral hippocampus (CA1) admin...