Commiphora mukul commonly known as Guggul is one of the oldest and commonly consumed herb for promoting heart and vascular health. Present study was undertaken to evaluate cardioprotective potential of Commiphora mukul against isoprenaline-induced myocardial necrosis in rats. Wistar albino rats were divided into three main groups: sham (saline only), isoprenaline control (saline and isoprenalin...

The antihyperlipidemic activity of resinoids of guggul (Commiphora mukul/Commiphora wightii), belonging to family Burseraceae (Genus: Commiphora), collected from different parts of India (Gujarat, Madhya Pradesh and Rajasthan), was studied on cholesterol-rich high fat diet-induced model of hyperlipidemia in rats. The resinoids of these exudates were prepared in ethyl acetate and ethyl alcohol. ...

The results of this study indicate that melatonin induces hypothyroidism in mice within eight days. Simultaneous administration of melatonin and petroleum ether extract of Commiphora mukul brings about a significant improvement in thyroid structure and function. Further, melatonin induced hypothyroidism is although a little reversible yet it is normalized quickly after C. mukul treatment. These...

The results of this study has revealed a significant increase in I(131) uptake of cultivated thyroid gland in the media containing petroleum ether extract of Commiphora mukul. Besides, T(3) resin uptake, protein bound iodine as well as free thyroxine index in the media are also observed to be significantly (P 0.001) increased. When explants are cultivated in the media containing melatonin, ther...

Gum Guggul (Commiphora mukul), Blue Flag root (Iris versicolor) and seaweeds such as Bladderwrack (Fucus vesiculosus) are naturally occurring compounds that may aid in the treatment of hypothyroidism. Because these work via different mechanisms, they may be combined to synergistically support the thyroidparticularly in situations of thyroid hypofunction and Hashimoto’s Disease. Fucus provides ...

There is accumulating evidence that LDL oxidation is essential for atherogenesis, and that antioxidants that prevent this oxidation may either slow down or prevent atherogenesis. In the present study, we found that Commiphora mukul and its cholesterol-lowering component, guggulsterone, effectively inhibited LDL oxidation mediated by either catalytic copper ions, free radicals generated with the...

This communication deals with the detailed pharmacognostical aspects of commiphora mukul leaves which include morphological and anatomical characters and preliminary phytochemical analysis of the leaves. The microscopical characters of leaf powder are also reported with its salient features. The fluorescent behaviour of powdered drugs with some chemical reagents is also examined.

materials and methods thirty-two adult male wistar rats were randomly allocated to four groups: normal, diabetic, normal + extract of c. mukul and diabetic + extract of c. mukul groups with free access to regular rat diet. diabetes was induced in male rats by single interaperitoneal injection of 60 mg/kg stz. after the confirmation of diabetes, 300 mg/kg c. mukul extract was orally administered...