The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy (FTIR), ultraviolet, differential scanning calor...

PURPOSE Carbamazepine is a poor water soluble drug and its bioavailability is limited by dissolution rate. Dissolution, serum concentration and anticonvulsive effect of the drug have been evaluated after cogrinding with microcrystalline cellulose. A cogrinding technique was used to increase the dissolution, serum concentrations and anticonvulsive effect of the drug. A novel deconvolution techni...

PURPOSE Low-frequency ultrasound has a significant effect on the transdermal permeation of high molecular weight drugs. However, the rate of permeation in pulsed mode is quite low necessitating considerable time to apply the ultrasound. 0.5 MHz ultrasound, which is a relatively higher frequency in the low-frequency range, can be applied in high intensity in continuous mode. METHODS A transduc...

In the present study, an attempt was made to increase the in vitro dissolution rate of carvedilol (antihypertensive) by cogrinding technique using various carriers, namely lactose, corn starch, treated agar, microcrystalline cellulose. The coground mixtures were prepared using the above excipients in four drug-carrier ratios, viz., 1:1, 1:3, 1:4 and 1:9. The prepared coground mixtures were eval...

carbamazepine belongs to the class ii biopharmaceutical classification system (bcs) which is characterized by a high per-oral dose, a low aqueous solubility and a high membrane permeability. the bioavailability of such a drug is limited by the dissolution rate. in order to increase the drug dissolution, its solid dispersions were prepared by the cogrinding technique using an insoluble but highl...

The objective of the present work was to enhance the solubility and dissolution of practically water-insoluble drug raloxifene HCl (RLX), for the same two approaches that were used. In the first approach, drug was kneaded with hydroxypropyl-β-cyclodextrin (HPβCD), and in the second one drug was cogrinded with modified guar gum (MGG). The drug-cyclodextrin complex and drug-MGG cogrind mixtures w...