Background: Cocaine poisoning is known for causing severe clinical effects such as tachycardia, hypertension, agitation and confusion. Absence of clinical manifestations in cocaine poisoning is unusual. Case report: A 26-year old man, known to be a cocaine addict, declared that he was forced by cocaine dealers to swallow many tablets of cocaine, six hours prior to admission to emergency departm...

background: cocaine poisoning is known for causing severe clinical effects such as tachycardia, hypertension, agitation and confusion. absence of clinical manifestations in cocaine poisoning is unusual. case report: a 26-year old man, known to be a cocaine addict, declared that he was forced by cocaine dealers to swallow many tablets of cocaine, six hours prior to admission to emergency departm...

in the present study, the effect of apamin (potassium channel blocker) on tolerance to cocaine-induced locomotor activity in mice has been investigated. locomotor activity was measured by locomotor activity meter, animax, type s (lkb, farrad). intraperitoneal (ip) injection of different doses of cocaine (2.5, 5, 10 and 15 mg/kg) produced dose-dependent locomotor activity in mice.animals were tr...

The effects of cholecystokinin (CCK) receptor antagonists on hypothermia induced by cocaine or morphine have been studied in mice. In the present work, subcutaneous (SC) injection of cocaine (50-150 mg/kg) or morphine (125-500 mg/kg) induced hypothermia in mice. Administration of CCKA receptor antagonist MK-329 (0.5-1.5 mg/kg), CCKB receptor antagonist L-365, 260 (0.5-1.5 mgl kg) and CCK r...

Objective(s): This paper describes a selective and sensitive biosensor based on the dissolution and aggregation of aptamer wrapped single-walled carbon nanotubes. We report on the direct detection of aptamer–cocaine interactions, namely between a DNA aptamer and cocaine molecules based on near-infrared absorption at λ807. Materials and Methods: First a DNA aptamer recognizing cocaine was non-co...

objective(s): this paper describes a selective and sensitive biosensor based on the dissolution and aggregation of aptamer wrapped single-walled carbon nanotubes. we report on the direct detection of aptamer–cocaine interactions, namely between a dna aptamer and cocaine molecules based on near-infrared absorption at λ807. materials and methods: first a dna aptamer recognizing cocaine was non-co...

conclusions the present study provides the first experimental evidence in support of dexmedetomidine treatment for cocaine-induced seizures. premedication with dexmedetomidine reduces seizure activity in a mouse model of acute cocaine toxicity. in addition, while dexmedetomidine may be effective, moxonidine and alpha-methyldopa did not effectively prevent cocaine-induced lethality. results the ...

Background: Prescription drug monitoring programs (PDMPs) are instrumental in controlling opioid misuse,but opioid users have increasingly shifted to cocaine, creating a different set of medical problems. Whileopioid use results in multiple medical comorbidities, findings of the existing studies reported singlecomorbidities rather...

cocaine is used by more than 14 million people worldwide, about 0.3 percent of the global population age is 15 to 64 years. after alcohol, cocaine is the most common cause of acute drug-related emergency department visits in the united states. cocaine consumption is more frequently associated with acute cardiovascular illness.  cocaine stimulates α 1 , α 2 , β 1 and β 2 adrenergic receptors thr...

the effects of cholecystokinin (cck) receptor antagonists on hypothermia induced by cocaine or morphine have been studied in mice. in the present work, subcutaneous (sc) injection of cocaine (50-150 mg/kg) or morphine (125-500 mg/kg) induced hypothermia in mice. administration of ccka receptor antagonist mk-329 (0.5-1.5 mg/kg), cckb receptor antagonist l-365, 260 (0.5-1.5 mgl kg) and cck recept...