Cobra snakebites are one of the most frequent occurrences among the poisonous snakebites. The correlation between the serum concentrations of cobra venom in the victims with the severity of systemic and local symptoms after envenoming is still awaited for investigation. In this paper, we have developed an enzyme-linked immunosorbent assay (ELISA) to detect Taiwan cobra venom existed in the seru...

teristic pharmacological properties. With this end in view we started with cobra venom and Russell's viper venom. The cobra and Russell's viper belong to two different families of snakes, viz, Colubridce and Viperidce, respectively, and though the venoms from these have some characteristics in common they differ strikingly in other respects. For instance the neurotoxic element is preponderant i...

The neutralizing capacity of antivenom prepared against Thai cobra (Naja kaouthia) venom was compared in mice using the homologous venom and that of spitting cobra (Naja siamensis). The amounts of antivenoms neutralizing a dose of 4 LD50 of the test venom were determined. Four antivenom preparations were used: three purified antivenoms and a crude antivenom, which were made using N. kaouthia ve...

BACKGROUND Chronic pain often results in cognitive impairment. Our previous study showed that trigeminal neuralgia induced by cobra venom leads to spatial learning and memory deficits, although the underlying mechanism remains unclear. However, recent evidence indicates that the c-AMP-responsive element binding protein (CREB)/brain derived neurotrophic factor (BDNF) pathway plays a critical rol...

the myocardial effect of snake venoms is considered as one of the most common pathogenesis in many cases of snake envenomation. this study was under taken to investigate the effects of snake (naja naja oxiana) venom on cardiac function in experimental animals. the blood samples from all the rabbits were collected before venom injection and then 140 µg/kg venom of snake (naja naja oxiana) was in...

Some constituents of snake venom have been found to display a variety of biological activities. The antibacterial property of snake venom, in particular, has gathered increasing scientific interest due to antibiotic resistance. In the present study, king cobra venom was screened against three strains of Staphylococcus aureus [including methicillin-resistant Staphylococcus aureus (MRSA)], three ...

Snake bite was known as one of the most important public health concerns world wild. Respiratory and cardiac problems and destruction of endothelium system occurs as a result of snake bite. Some proteins and peptides in snake venom have potential for drug discovery studies. According to the important role of cell adhesion and angiogenesis in cancer development, identification of new therapeutic...

Mucuna pruriens has been used by native Nigerians as a prophylactic for snakebite. The protective effects of M. pruriens seed extract (MPE) were investigated against the pharmacological actions of N. sputatrix (Javan spitting cobra) venom in rats. The results showed that MPE-pretreatment protected against cardiorespiratory and, to a lesser extent, neuromuscular depressant effects of N. sputatri...

Chinese Cobra (Naja naja atra) bite is one of the leading causes of snake-bite mortality in China. The traditional anti-cobra venom serum therapy was found to be expensive and with high frequency of side effects. Therefore attempts were made to generate a high titer immunoglobulin from egg yolk (IgY) of crude cobra-venom immunized Leghorn hens, and to standardize an effective method for produci...