Thirty patients with various types of chronic liver disease and a prothrombin time prolonged for four or more seconds who required needle liver biopsy for diagnostic purposes were given either fresh frozen plasma or a concentrate of clotting factors as a prophylactic measure. The prothrombin time returned to within normal limits in seven of the 15 patients given the concentrate and in three of ...

P APER STRIP and paper curtain electrophoretic technics have been widely used to separate or identify clotting factors.19 Recently, starch gel electrophoresis has also been employed.9’10 We report herein the results of starch block electrophoresis using starch thoroughly washed with ethylenediaminetetraacetate ( EDTA). We have characterized the migration pattern of the following plasma clotting...

conclusions the case was fully investigated and diagnosed as a case with factor xiii deficiency causing such uncontrolled bleeding after extraction of a tooth. introduction factor xiii deficiency is a relatively rare hereditary bleeding disorder, which is usually found during infancy or early childhood. this condition may involve both genders within different races in an equal manner. its incid...

Objective. The aim of this study was to identify routinely available clinical surrogate markers for potential clotting factor alterations following multiple trauma. Methods. In 68 patients admitted directly from the scene of the accident, all soluble clotting factors were analyzed and clinical data was collected prospectively. Ten healthy subjects served as control group. Results. Patients show...

Marcumar has been considered as an excellent anticoagulant for long term management. It was found that the effect of the drug on plasma levels of prothiombin and autoprothrombin I and autoprothrombin II differed from that of the drugs previously studied using the technics described. Autoprothrombin II was not reduced by Marcumar. This clotting factor, autoprothrombin II, has been found to have ...

A patient with a significant history of spontaneous and posttraumatic bleeding was found to have hypoprothrombinemia. His prothrombin (factor II) activity by clotting assay was 9.5% and his factor II antigen was 5%. Crossed immunoelectrophoresis and sucrose density gradient ultracentrifugation of the patient's plasma showed his prothrombin to be qualitatively indistinguishable from normal proth...

The association between nephrotic syndrome (NS) and intravascular coagulation is well known, and thromboembolic disease is a relatively common complication of the condition. The association of NS with anticoagulant activity is less well recognized. Factor X deficiency, and sometimes Factor IX and Factor II deficiency, can rarely complicate AL amyloidosis, which may present with a NS. The mechan...

Using specimens from a population-based case control study among women ages 18 to 44 years in western Washington, we assessed the relationship between carriership of a genetic clotting factor II variant (20210 G-->A) and myocardial infarction (MI). The factor II variant was previously shown to be present in 1% to 2% of the population, to increase the levels of factor II, and to be associated wi...