background: the role and proper dose of pralidoxime in the treatment of organophosphorus (op) compounds poisoning is an unresolved issue .this study was designed to compare the regimen recommended by the world health organization (who) with the commonly used standard regimen of pralidoxime. methods: this was a randomized open labeled prospective study on op poisoned patients admitted to jss hos...

The initial clinical presentation of amitraz and organophosphate poisoning may be similar. Reduced serum pseudocholinesterase supports a diagnosis of organophosphate toxicity, but there is no similar laboratory test for amitraz poisoning. A 'mothball-like' odour associated with poisoned patients may have diagnostic potential. In a blinded controlled trial, 83% (95% confidence interval, 63% to 9...

background:acute poisoning with organophosphorus (op) pesticides is a common method of suicide and entails considerable mortality in bangladesh. the objective of this study was to evaluate the effects and outcomes of a protocol for treatment of op poisoning that included titrated incremental atropine as loading dose and slow infusion for maintenance.  methods:in this prospective descriptive cas...

BACKGROUND Previous studies stating a high prevalence of occupational acute pesticide poisoning in developing countries have mainly relied on measurements of the rather non-specific self-reported acute pesticide poisoning symptoms. Only a few studies have measured the biomarker plasma cholinesterase (PchE) activity, in addition to the symptoms, when assessing occupational acute pesticide poison...

BACKGROUND Many patients with organophosphate poisoning require mechanical ventilation. Muscle acetylcholinesterase (AChE) activity determines the impairment of muscle force generation, and red blood cell (RBC) AChE has been regarded as a surrogate for muscle AChE in organophosphate poisoning. Therefore, this study was conducted to investigate whether RBC AChE at presentation can predict the du...

background: for effective treatment of organophosphate (op) poisoning, development of a standardized protocol with flexible dose regimen for atropine and pralidoxime is an essential step. in this study, we aimed to assess the protocol devised in our setting; bach mai hospital poison treatment center, for treatment of op poisoning that included a higher dose regimen of pralidoxime (2pam). method...

Self-poisoning with organophosphate pesticides is a major health problem world-wide. Through the inhibition of acetylcholinesterase, organophosphorus poisoning is characterised by the clinical picture of acute cholinergic crisis. Other manifestations are the intermediate neurotoxic syndrome and delayed polyneuropathy. In the Western world, the occurrence of organophosphorus poisoning is less pr...

With the establishment of the inadequate efficiency of atropines and oximes in reducing morbidity and mortality of patients poisoned by organophosphates, more attention is given to using other methods such as Fresh Frozen Plasma (FFP) as a bioscavenger to mop up organophosphate toxins. This randomized clinical trial was conducted on 56 organophosphate poisoned patients who were randomly assigne...

BACKGROUND An estimated 2-3 million people are acutely poisoned by organophosphorus pesticides each year, mostly in the developing world. There is a pressing need for new affordable antidotes and clonidine has been shown to be effective in animal studies. Our aim was to determine the safety of clonidine given as an antidote in adult patients presenting with signs or symptoms of acute organophos...

Organophosphate poisoning is characterised for the most part, by acute incidents. Management is by way of first aid (in mild poisoning) and use of atropine with or without the oximes, (in moderate to severe poisoning). Of late, it has become apparent that subchronic and chronic organophosphate poisoning are a common manifestation. This review paper summarises this triphasic nature of organophos...