background: papillon-lefevre syndrome (pls) is a rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and early development of aggressive pe-riodontitis. although cathepsin c (ctsc) gene mutations have been established in about 70-80% of pls patients, it is assumed that the patients may have dysfunctioning of immune defense mechanisms. objective: to assess the associat...

previous studies have demonstrated some significant differences in hla allele frequencies in leukemic patients and normal subjects. we have analyzed hla class ii alleles and haplotypes in 60 iranian patients with acute myelogenous leukemia (aml) and 180 unrelated normal subjects. blood samples were collected after obtaining informed consents. from the patients and control dna extraction and hla...

background: functional appliances such as bionator have been used to treat class ii malocclusion. the purpose of this study was to compare the skeletal, dental and soft tissue effects of bionator appliances with multi-p (a newly developed appliance) in the treatment of class ii malocclusion. subjects and methods: 45 class ii children were chosen and randomly assigned to either the bionator or m...

major histocompatibility complex (mhc) class ii deficiency is a primary immunodeficiency disease characterized by abnormality of mhc class ii molecules surface expression on peripheral blood lymphocytes and monocytes. clinical manifestations include extreme susceptibility to viral, bacterial, and fungal infections but the immunodeficiency is not as severe as scid (severe combined immunodeficien...

objective: attempts to treat class ii malocclusions without extraction in non-compliant patients have led to utilization of intraoral molar distalizing appliances. the purpose of this study was to investigate dental and skeletal effects of bonded molar distalizer (bmd) which is a simple molar distalizing appliance. materials and methods: sixteen patients (12 girls, four boys) with bilateral hal...

statement of problem: assessment of mandibular size and position is essential when planning a treatment strategy for patients with class ii malocclusion. purpose: this study was carried out to evaluate the mandibular size and position of 8-13 year-old children with class ii division 1 malocclusion whom were referred to the faculty of dentistry, shiraz university of medical sciences, iran. mater...