currently cancer is considered as one of the main factors of mortality globally. many chemicals in our environment can cause genetic mutations and are potentially responsible for millions of cancer-related deaths. nowadays the scientists are looking for food materials which can potenthially prevent the cancer occurrence. the purpose of this research is to examine antimutagenicity and anticancer...

Fruit juice-drug interactions involving drug transporters and metabolic enzymes have been studied with various citrus fruit juices. The collective data led us to hypothesize that the modulating activity of citrus fruit juices on cellular transport and metabolic pathways is dependent on the dominant flavonoid pattern and taxonomy of the citrus fruits. This hypothesis has important implications g...

Kinnow (Citrus nobilis × Citrus deliciosa L.) is a widely grown Citrus species known for its high quality fruit juice with good storage life. The present investigation is concerned with the enhancement of shelf-life of Kinnow fruit juice through refrigeration storage and addition of preservatives. Fruit juice was prepared from fruits harvested at complete physiological maturity and potassium me...

The present study aims at the phytochemical profiling of lyophilized pure fruit juice powder of Citrus limon and demonstrates its efficacy as an antitumor agent against human breast cancer cell line (MCF-7). The cytotoxicity was evaluated using the changes in cell morphology, cell viability, and DNA fragmentation, the percentage of cell viability was determined by MTT assay. Our results showed ...

OBJECTIVES To describe the contribution of whole fruit, including discrete types of fruit, to total fruit consumption and to investigate differences in consumption by sociodemographic characteristics. METHODS We analyzed data from 3129 youth aged 2 to 19 years from the National Health and Nutrition Examination Survey, 2011 to 2012. Using the Food Patterns Equivalents Database and the What We ...

The capacities of citrus fruits to inhibit midazolam 1'-hydroxylase activity of cytochrome P450 3A (CYP3A) expressed in human liver microsomes were evaluated. Eight citrus fruits such as ama-natsu, banpeiyu, Dekopon, hassaku, hyuga-natsu, completely matured kinkan (Tamatama), takaoka-buntan and unshu-mikan were tested. We also examined the inhibition of CYP3A activity by grapefruit (white) and ...

Recently, the prevalence of allergies in Japan has been increasing. Certain types of fruit juice and lactic acid bacteria are known to alleviate allergic symptoms. Therefore, we examined whether citrus juice fermented by a specific lactic acid bacteria can improve the symptoms of Japanese cedar pollinosis (JCPsis). Lactobacillus plantarum YIT 0132 (LP0132) was selected based on its high prolife...

Organic cation transporter 2 (OCT2) plays an important role in the renal clearance of endogenous and exogenous organic cations, including drugs and their metabolites. Citrus fruit juice interactions with the P-gp efflux transporter are well-established, but there is to date no study on the effects of citrus fruit juice on OCT2 function and expression. This paper evaluates the modulating activit...

The demand of fruit juices is increasing day by day as a result of increasing health awareness among the people. Most of juice extraction processes are not producing satisfactory quantity and quality of juices. Enzymatic extraction of juices results in higher yield. The enzymes used are mainly pectinase, cellulase, hemicellase etc. Apart from promoting juice extraction, enzyme addition increase...

Organic acid accumulation in the vacuole of juice cells of citrus fruits is a developmentally regulated process, the degree and timing of which varies greatly among species and varieties and is highly susceptible to environmental conditions (Clements, 1963; Ting and Vines, 1966; Vandercook, 1977). Total titratable acidity of the fruit juice of the acidless pummelo 2240 (Citrus maxima [Burm.] Me...