abstract introduction: in this study the role of pge2 as an important inflammatory mediator in indomethacine and theophylline effects on joint diameter and vascular response of chronically inflamed rat knee joint to saphenous nerve stimulation was investigated. methods: inflammation was induced by intraarticular injection of 0.2 ml freund,s complete adjuvant (fca) and 3, 7, 14, 21 days post inj...

introduction: stress is defined as any environmental change that disturbs the maintenance of brain homeostasis. stress leads to production of pro-inflammatory cytokines that provoke neurodegenerative disorders. in the present study, we investigated the effects of dalteparin on hippocampal neuronal death induced by chronic stress in rats. methods: the study was carried out on 60 adult male wista...

prohibitins are chaperone proteins highly conserved among eukaryotes. many different functions have been attributed to prohibitins depending on their tissue expression and sub-cellular localization. prohibitins play a major role in mitochondrial physiology, regulating the stability and the processing of both respiratory chain complex subunits and opa1, a mitochondrial fusion regulating protein....

introduction: full crown preparation may have adverse effects on pulp tissue. in this study, the effect of full-crown preparation on intact versus inflamed pulp tissue was studied. methods: fifteen healthy mature cats were randomly selected for this study. the study was performed on four canine teeth of each cat. cats were anesthetized and then radiographs were taken from the canine teeth. clas...

abstract objective: obesity is related to anemia which is explained its mechanism as disorder in iron absorption but the more rational reason is anemia of inflammation or anemia of chronic disease. the aim of this study was to define the prevalence of obesity in patients with normochromic normocytic anemia. materials and methods: we screened 406 patients who were referred to endocrine clinic. t...

background: transferrin is a negative acute phase protein, which decreases during inflammation and infection. the aim of the present study was to evaluate changes in the transferrin serum levels subsequent to non-surgical treatment of chronic periodontal disease. methods: twenty patients with chronic periodontitis and 20 systemically healthy subjects without periodontal disease, who had referre...

cyclizine (1-benzhydryl-4-methyl-piperazine, cas 82-92-8, cyc, i), a piperazine derivative, belongs to h1 antihistamine group of drugs that shows such pharmacological properties as anti-inflammatory, anti-allergic and anti-platelet effects, similar to other h1-receptor antagonists. in this study, two new tolyl and cumene derivatives of i (1-ethyl-4-[(p-isopropylphenyl) (p-tolyl) methyl]-piperaz...

conclusions this study focused on important effects of malnutrition and inflammation on health-related quality of life aspects, both physically and mentally in hd patients. sga and mis are highly correlated with quality of life in hd patients. background malnutrition, inflammation and poor quality of life are prevalent among hemodialysis (hd) patients. health-related quality of life is an impor...

recent studies suggested the role of white blood cells (wbcs) in the pathogenesis and complications of type 2 diabetes. increased wbc counts predict mortality in patients with chronic kidney disease (ckd). in this study alterations in wbc subpopulations in diabetic patients with non-dialysis dependent ckd are investigated. this was a cross-sectional study  on 376 participants, including   272 d...

background and objectives: the cause and pathophysiology of rheumatoid arthritis has not been fully understood and an experimental model of this disease is essential for research on the problem. in this research study, establishment and histopathological changes of chronic arthritis due to intra-articular antigen injection was used as a model of experimental rheumatoid arthritis. materials and ...