Introduction: Chronic pancreatitis is defined as a persistent pancreatic inflammatory disease. In chronic pancreatitis, recurrent episodes of inflammation lead to the replacement of pancreatic parenchyma with fibrotic connective tissue. Chronic pancreatitis pain, which may initially mimic acute pancreatitis, is severe, frequent, and continual and has a major impact on the quality of life and so...

To date, there is no consensus on the evolution of chronic pancreatitis. Comfort's initial proposal of acute pancreatitis progressing to chronic pancreatitis was discarded by protagonists of the 'separate' theory. Sarles thus stresses the de novo evolution of chronic pancreatitis-acinar protein hypersecretion associated with an imbalance of pancreatic stone promoting and inhibiting factors. How...

BACKGROUND The biological basis of pain in chronic pancreatitis is poorly understood. Mast cells have been implicated in the pathogenesis of pain in other conditions. We hypothesized that mast cells play a role in the pain of chronic pancreatitis. We examined the association of pain with mast cells in autopsy specimens of patients with painful chronic pancreatitis. We explored our hypothesis fu...

CONTEXT Growing evidence suggests that recurrent acute pancreatitis leads to chronic pancreatitis, but this sequence is seldom reported in human subjects. The sentinel acute pancreatitis event hypothesis suggests that an initial episode of acute pancreatitis is the first step in a complicated series of events ultimately leading to chronic pancreatitis. OBJECTIVE To identify patients who evolv...

Chronic pancreatitis Chronic pancreatitis, that is chronic progressive replacement fibrosis of the pancreas, is a rare disease in this country. I have collected fifty-five cases (thirty-six women and nineteen men) who illustrate some aspects of the disease, but I have had to rely on the literature for most of my information. The literature on chronic pancreatitis has been very confused and one ...

Cassava is a high carbohydrate, low protein food source that has been previously implicated to cause tropical chronic pancreatitis in developing countries Recently it has been disproven as a sole cause of chronic pancreatitis, however, its role as a possible cofactor (due to high levels of cyanogens) contributing to the development of pancreatitis cannot be ruled out. Alcohol is a well-known ri...

HYPOTHESIS After alcohol-induced and hereditary disease, idiopathic chronic pancreatitis is the most common cause of calcifying pancreatitis. This designation is used when no associated cause of chronic pancreatitis is found. We present 6 cases of idiopathic pancreatitis in which the postoperative pathological examination results demonstrated lymphoplasmacytic sclerosing pancreatitis or autoimm...