Human brucellosis is a major health problem in developing countries. A number of patients with human brucellosis do not recover from the acute stage of the disease and pass into the chronic form. Since the pathophysiology of this change is not well understood, we studied the T-cell subsets during the acute, subacute and chronic forms of human brucellosis. In this study we found alterations...

human brucellosis is a major health problem in developing countries. a number of patients with human brucellosis do not recover from the acute stage of the disease and pass into the chronic form. since the pathophysiology of this change is not well understood, we studied the t-cell subsets during the acute, subacute and chronic forms of human brucellosis. in this study we found alterations in t...

Background: Brucella is a well-known intracellular bacterium entailing acute and chronic illnesses in humans and domestic animals. The infection chronicity may be affected by the cell-mediated immunity and cytokine patterns. Objective: To evaluate the patterns of T-helper cytokines in patients suffering from chronic and acute brucellosis. Methods: In this cross-sectional study, 22 individuals w...

brucellosis is an endemic zoonotic infectious disease in middle east countries including iran. this infection may involve central nervous system. psychosis has been reported in rare cases with chronic brucellosis. a 26-year-old male shepherd patient who developed neuro-brucellosis and psychosis is presented. he had hallucinations (visual and auditory) and delusions. he was also impulsive and ha...

OBJECTIVES Brucellosis remains one of the most common zoonotic diseases worldwide. In humans, brucellosis can be a serious, debilitating, and sometimes chronic disease. Different mechanisms can be postulated as to the basis for the induction of the chronic status of infectious diseases that T regulatory cells are one of the most important related mechanisms. The current study was designed to de...

background:   brucellosis is one of the most common chronic diseases, with widespread distribution. in spite of cell-mediated immunity (cmi) modulated mainly via activated t-helper type 1 (th1) cells, brucellosis can advance to chronic disease in about 10-30% of cases. regulatory t cells (treg cells) are involved the immune response to brucellosis; however, their role, particularly in the chang...

Background:   Brucellosis is one of the most common chronic diseases, with widespread distribution. In spite of cell-mediated immunity (CMI) modulated mainly via activated T-helper type 1 (Th1) cells, brucellosis can advance to chronic disease in about 10-30% of cases. Regulatory T cells (Treg cells) are involved the immune response to brucellosis; however, their role, particularly in...

Brucellosis is an endemic zoonotic infectious disease in Middle East countries including Iran. This infection may involve central nervous system. Psychosis has been reported in rare cases with chronic brucellosis.A 26-year-old male shepherd patient who developed neuro-brucellosis and psychosis is presented. He had hallucinations (visual and auditory) and delusions. He was also impulsive and had...