• The chondron concept was first introduced in 1925 by Benninghoff who used polarised light microscopy to show that the chondrocyte in hyaline cartilages was surrounded by a specialised region of matrix. However, this concept was not widely accepted a (the time, audit was until 1969 that Szirmai rekindled interest in the chondron concept. Using new histochemical interpretations coupled with rni...

BACKGROUND Dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. Chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. The chondrocyte is surrounded by a pericellular matrix (PCM), together forming the chondron. PCM has a positive effect on the maintenance of chondrocyte phenotype during culture in compariso...

Background Osteoarthritis is a degenerative disease involving diarthrosis articulations. The evolution of the disease is very slow; the first changes regard the cellmatrix morpho-functional unit of articular cartilage called chondron by Benninghoff. The articular cartilage modifications are progressive from the superficial layer through the intermedial and the deep layer. Authors analyzed the u...

Introduction: Chondrocytes within articular cartilage are surrounded by a complex pericellular microenvironment which, together with the cell, is termed the chondron. The mechanical and physicochemical properties of the chondron matrix will undoubtedly influence the metabolism of the chondrocytes and their response to joint loading. The aim of the present study was to examine cell morphology in...

BACKGROUND Gel-type autologous chondrocyte (Chondron) implantations have been used for several years without using periosteum or membrane. This study involves evaluations of the clinical results of Chondron at many clinical centers at various time points during the postoperative patient follow-up. METHODS Data from 98 patients with articular cartilage injury of the knee joint and who underwen...

The pericellular matrix (PCM) is the narrow tissue region surrounding all chondrocytes in articular cartilage and, together, the chondrocyte(s) and surrounding PCM have been termed the chondron. Previous theoretical and experimental studies suggest that the structure and properties of the PCM significantly influence the biomechanical environment at the microscopic scale of the chondrocytes with...

background dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. the chondrocyte is surrounded by a pericellular matrix (pcm), together forming the chondron. pcm has a positive effect on the maintenance of chondrocyte phenotype during culture in compariso...

A heterogenous population of intact chondrons extracted from low-speed homogenates of canine tibial cartilage were stained by indirect immunofluorescence methods with a polyclonal antibody to type VI collagen. In each of the four chondron groups examined, anti-(type VI collagen) anti-serum was concentrated in the capsule immediately adjacent to the chondrocyte complex. A constant but weaker flu...

BACKGROUND Dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. Chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. The chondrocyte is surrounded by a pericellular matrix (PCM), together forming the chondron. PCM has a positive effect on the maintenance of chondrocyte phenotype during culture in compar...

OBJECTIVE To assess the ability of nonlinear optical microscopy (NLOM) to image ex vivo healthy and degenerative bovine articular cartilage. METHOD Fresh bovine femoral-tibial joints were obtained from an abattoir. Articular cartilage specimens were harvested from the tibial plateau. Normal and degenerative specimens were imaged by NLOM and subsequently fixed and processed for histological ex...