the purpose of this report is to present the results of analysis of actual glucosamine and/or chondroitin contents of several such products in the market place and to determine if they significantly deviate from their label claim. a total of fourteen products containing glucosamine sulfate and nine products containing chondroitin sulfate were evaluated. the amounts of glucosamine and chondroiti...

The purpose of this report is to present the results of analysis of actual glucosamine and/or chondroitin contents of several such products in the market place and to determine if they significantly deviate from their label claim. A total of fourteen products containing glucosamine sulfate and nine products containing chondroitin sulfate were evaluated. The amounts of glucosamine and chondroiti...

The purpose of this report is to present the results of analysis of actual glucosamine and/or chondroitin contents of several such products in the market place and to determine if they significantly deviate from their label claim. A total of fourteen products containing glucosamine sulfate and nine products containing chondroitin sulfate were evaluated. The amounts of glucosamine and chondroiti...

Chondroitin sulfate is a major component of the extracellular matrix in both the central and peripheral nervous systems. Chondroitin sulfate is upregulated at injury, thus methods to promote neurite extension through chondroitin sulfate-rich matrices and synthetic scaffolds are needed. We describe the use of both chondroitin sulfate and a novel chondroitin sulfate-binding peptide to control the...

Bovine aortic endothelial cells were cultured in medium containing [3H]glucosamine and concentrations of [“S]sulfate ranging from 0.01 to 0.31 mM. While the amount of [‘H]hexosamine incorporated into chondroitin sulfate and heparan sulfate was constant, decreasing concentrations of sulfate resulted in lower [‘“SIsulfate incorporation. Sulfate concentrations greater than 0.1 1 mM were required ...

Chondroitin sulfate (CS) is widely used across the world as a nutraceutical and pharmaceutical. Its high demand potential limitations in current methods of extraction call for an alternative method production. This review highlights glycosaminoglycan’s structure, its medical significance, animal source, disadvantages process. We cover production strategies CS precursor, chondroitin. highlight c...

Umbilical cord was shown to contain chondroitin sulfate B and a small amount of glucosamine-containing sulfated mucopolysaccharide, in addition to hyaluronic acid and chondroitin sulfate C. All of the hyaluronic acid and part of the chondroitin sulfate C could be extracted directly with dilute sodium chloride; the rest of the chondroitin sulfate C and the chondroitin sulfate B were released onl...

We have previously shown that in confluent human fibroblast cultures chondroitin sulfate proteoglycan is a component of the fibronectin-containing pericellular matrix fibers. In the present work the distribution of chondroitin sulfate was studied in subconfluent cell cultures using antibodies that bind to a chemically defined carbohydrate fragment of chondroitinase ABC-modified chondroitin sulf...

Cultured monolayers of NMuMG mouse mammary epithelial cells have augmented amounts of cell surface chondroitin sulfate glycosaminoglycan (GAG) when cultured in transforming growth factor-beta (TGF-beta), presumably because of increased synthesis on their cell surface proteoglycan (named syndecan), previously shown to contain chondroitin sulfate and heparan sulfate GAG. This increase occurs thro...

Primary cell cultures of differentiated chondrocytes were shown to produce chondroitin-4-sulfate as the predominant mucopolysaccharide, with suggestive evidence for the synthesis of keratan sulfate and possibly chondroitin-6-sulfate. Chicken embryonic cartilage was shown to be composed mainly of chondroitin-4-sulfate, with a small amount of chondroitin-6-sulfate, but essentially no keratan sulf...