Three experiments were conducted to study the dietary choline requirement of young swine. Ninety pigs (three replicates), in the first experiment, and 120 pigs (four replicates), in the second experiment, were allotted to the five choline treatments (0, 330, 660, 990 or 1320 mg choline/kg of diet), fed in a 23% crude protein, semi-purified diet (.31% methionine, .33% cystine). The combined resu...

One of the underlying mechanisms for metabolic individuality is genetic variation. Single nucleotide polymorphisms (SNPs) in genes of metabolic pathways can create metabolic inefficiencies that alter the dietary requirement for, and responses to, nutrients. These SNPs can be detected using genetic profiling and the metabolic inefficiencies they cause can be detected using metabolomic profiling....

In our recent investigation we have studied the effect of high dose of choline and riboflavin on the fecal excretion of cholesterol and bile acids of albino rats kept on a high cholesterol diet and found that choline increased the fecal excretion of bile acid without showing any appreciable in crease in the excretion of cholesterol in feces. Riboflavin did not show any appreci able increase or ...

PURPOSE OF REVIEW Choline is an essential nutrient and the liver is a central organ responsible for choline metabolism. Hepatosteatosis and liver cell death occur when humans are deprived of choline. In the last few years, there have been significant advances in our understanding of the mechanisms that influence choline requirements in humans and in our understanding of choline's effects on liv...