OBJECTIVE To determine whether middle ear cholesteatoma is associated with, sensorineural hearing loss, and whether patient age, cholesteatoma growth pattern, or, air bone gap size contribute to inner ear impairment. STUDY DESIGN Cross-sectional comparative. SETTING A tertiary hospital. PATIENTS The subjects were 115 patients with middle ear cholesteatoma in one ear, and normal video-otos...

There are two types of cholesteatoma in children, congenital and acquired. The pathogenesis of each type is thought to be different. The pathogenesis of congenital cholesteatoma is thought to be the embryonic inclusion of squamous epithelium, whereas acquired cholesteatoma is thought to develop from various factors including recurrent otitis media and tubal insufficiency. We reviewed a series o...

In order to provide a basis for meaningful exchange of information among those treating cholesteatoma, the Committee on Nomenclature of the Japan Otological Society (JOS) was appointed in 2004 to create a cholesteatoma staging system as simple as possible to use in clinical practice in Japan. Following the announcement of preliminary criteria for the staging of pars flaccida (attic) cholesteato...

The tumor suppressor CYLD is a deubiquitinating enzyme that inhibits activation of the NF-kappaB, which has key roles in inflammation and apoptosis. We hypothesized that CYLD may regulate the NF-kappaB signaling pathway in cholesteatoma. We conducted immunohistochemistry to examine the expression of CYLD and NF-kappaB in 16 cases of cholesteatoma and paired cases of retroauricular (RA) skin. In...

Objective. Bilateral congenital cholesteatoma is a very rare condition. We describe the first case of an adult patient presenting with bilateral congenital cholesteatoma with labyrinthine fistula. Case report. We present a 34-year-old woman of bilateral congenital cholesteatoma with labyrinthine fistula, inducing leftsided mixed conductive-sensorineural hearing loss and vertigo, subsequently ac...

INTRODUCTION Acquired middle ear cholesteatoma can be classified as primary or secondary. Although both can result in hearing loss, it is still controversial whether there is an association between the type of cholesteatoma and the degree of hearing loss. OBJECTIVE To analyze the association between hearing loss and the type of acquired cholesteatoma, and the status of the ossicular chain. ...

Aim: To differentiate cholesteatoma from non cholesteatoma (control) CSOM on simple clinical grounds for its early detection and management. Methods: A series of 156 patients (aged 5-64-years of either sex) having atticoantral (unsafe) ear disease, including 94 patients with cholesteatoma CSOM and 62 patients of CSOM without cholesteatoma (controls) were inducted in the study. The clinical sign...

Cholesteatoma is a serious otolaryngologic condition that to date remains an important problem and poses a challenge to otolaryngologists around the world. To improve the approach pertaining to the diagnosis and management of middle ear cholesteatoma, clear, clinically applicable, and useful definition and classification of cholesteatoma are required. This review aimed to evaluate the current a...

Background: Cholesteatoma is a collection of keratinized squamous epithelium in middle ear and pneumatic areas temporal bone. It can be said as an invasive disease which often associated with sensorineural hearing loss. seen that loss varies the location disease, duration extension cholesteatoma. Aims Objectives: The aim this study to see association cholesteatoma bone conduction threshold diff...

Seventy-three cases of adult cholesteatoma, including 52 cases with pars flaccida type cholesteatoma and 21 with pars tensa type cholesteatoma, were examined using high resolution computed tomography, in both axial (lateral semicircular canal plane) and coronal sections (cochlear, vestibular and antral plane). These cases were classified into two subtypes according with the presence of extensio...