A flow-injection coulometric method for the determination of chlorpromazine based on ion transfer into a plasticized poly(vinyl chloride) (PVC) membrane, was developed. The detector used consists of a flow-through cell that incorporates a plasticized poly(vinyl chloride) (PVC) membrane which contains tetrabutylammonium tetraphenylborate as electrolyte. The membrane is located between the flowin...

For the first time electron spin resonance (ESR) spectroscopic technique has been used for a highly selective determination of chlorpromazine. The method is based on the oxidation reaction of chlorpromazine with cerium(IV) in sulfuric acid media. In this method 3.8x10(-3) mol dm(-3) cerium(IV) was used in 0.035 mol dm(-3) sulfuric acid with the ESR spectra recorded at room temperature. A calibr...

A simple, rapid, precise, and accurate method is described for the simultaneous and quantitative determination of conjugated and unconjugated chlorpromazine metabolites in urine. It depends on reduction of sulfoxides to sulfides, and oxidation of sulfides to ion radicals in a solution of Fe-I-a (lO-N) in l8N H2S04.Absorbance is measured at 422, 530, 565, and 700 nm, and concentration of metabol...

The phenothiazine derivatives such as: promethazine, chlorpromazine and thioridazine hydrochlorides are used as psychotropic, neuroleptic, local anesthetics, anti-allergic and antiyomiting drugs [1]. The therapeutic interest in these compounds group justifies research to establish different analytical methods for the determination of these drugs in pharmaceutical preparations and biological sam...