BAckground Chloride channels have already been over-expressed in the different types of cancer. Chlorotoxins, as the blocking agent of these channels, have been indicated to be an effective drug against tumors. In this study, we characterized a putative chlorotoxin from a cDNA library of the venom glands obtained from the Iranian scorpion Odontobuthus doriae. Methods A cDNA library was constr...

Chlorotoxin is a small 36 amino-acid peptide identified from the venom of the scorpion Leiurus quinquestriatus. Initially, chlorotoxin was used as a pharmacological tool to characterize chloride channels. While studying glioma-specific chloride currents, it was soon discovered that chlorotoxin possesses targeting properties towards cancer cells including glioma, melanoma, small cell lung carcin...

background: chlorotoxin is a 36-amino acid peptide found in the venom of the leiurus quinquestriatus which blocks small-conductance chloride channels. chlorotoxin binds preferentially to glioma cells that allow development of new methods for the treatment and diagnosis of several types of cancer. thus chlorotoxin derivative was labeled with 131i for further investigation. materials and methods:...

Background: Chlorotoxin is a 36-amino acid peptide found in the venom of the Leiurus quinquestriatus which blocks small-conductance chloride channels. Chlorotoxin binds preferentially to glioma cells that allow development of new methods for the treatment and diagnosis of several types of cancer. Thus chlorotoxin derivative was labeled with 131I for further investigation. Materials and...

Glioblastoma multiforme (GBM) is the most common malignant primary brain neoplasm having a mean survival of <24months. Scorpion toxins are considered promising cancer drug candidates, primarily due to the discovery of hlorotoxin, derived from the venom of the Israeli yellow scorpion. This intriguing short peptide of only 36 amino-acids length and tight configuration, possess the ability to bind...

Chlorotoxin is a disulfide-rich stable peptide from the venom of the Israeli scorpion Leiurus quinquestriatus, which has potential therapeutic applications in the treatment of cancer. Its ability to preferentially bind to tumor cells has been harnessed to develop an imaging agent to help visualize tumors during surgical resection. In addition, chlorotoxin has attracted interest as a vehicle to ...

Chlorotoxin is a 36-amino acid peptide derived from Leiurus quinquestriatus (scorpion) venom, which has been shown to inhibit low-conductance chloride channels in colonic epithelial cells. Chlorotoxin also binds to matrix metalloproteinase-2 and other proteins on glioma cell surfaces. Glioma cells are considered to require the activation of matrix metalloproteinase-2 during invasion and migrati...

Nature inspires us to address the most contemporary scientific challenges. Advances in the drug delivery system at the nano/micro-scale hold promise to treat some fatal diseases in the next few decades. Scientists have discovered that the biomolecule Chlorotoxin, a naturally occurring biomaterial, can target tumor cells in the human brain with great precision. The application of Chlorotoxin can...

background: meict is the first chlorotoxin-like peptide isolated from the iranian scorpion mesobuthus eupeus. chlorotoxin (ctx) is a neurotoxin that specially binds to (mmp-2) on ma-lignant cells and now is used in treatment of glioma. in the present study, we have used homology modeling to propose the 3d structure of meictand analyze its interaction with mmp-2 and its snp types. methods:the st...