Human toxicity Chloroquine is a potentially fatal poisoning, often characterized by rapid deterioration. Features of toxicity may develop within 1 to 2 h, and death may occur abruptly, generally from myocardial depression and dysrhythmia. Symptoms at an acute overdose are as following: hyperexcitability, agitation, seizures, cerebral edema, ventricular dysrhythmia, hypotension, shock, cardiac a...

The effects of chloroquine on the growth and morphology of fibroblasts in tissue culture, and in vivo granulomas were investigated. As the result, the drug was shown to have a potent action to inhibit fibroblast growth, which has led to a possibility of its clinical use to patients with malignant tumors. ∗PMID: 14165348 [PubMed OLDMEDLINE] Copyright c ©OKAYAMA UNIVERSITY MEDICAL SCHOOL Acta Med...

The antimalarials are one of the most commonly prescribed drugs for conditions such as lupus erythematosus and rheumatoid arthritis, and the side effects, though infrequent, are well known. The antimalarial agent chloroquine diphosphate usually causes pigmentary changes in the oral mucosa characterized by a bluish-grey to black discolorations mainly in the hard palate. Considering only the hard...

A morphological, biochemical and physiological study has been made of the effects of chloroquine-diphosphate (a membrane stabilizer) on the preservation of buffalo spermatozoa in five modified dilutors designated here as Al’ A2’ A3, A4 and CAW. In almost all the five dilutors, there was significant (p< 0.01) progressive increase in the percentage of sperm abnormalities and the release of enzyme...

Objective(s): Drug delivery is an engineering technology to control the release and delivery of therapeutic agents to target organs, tissues, and cells. Metallic nanoparticles, such as gold nanoparticles (AuNPs) have exceptional properties which enable efficient drug transport into different cell types with reduced side effects and cytotoxicity to other tissues.Materials and Methods: AuNP...

Objective(s): Drug delivery is an engineering technology to control the release and delivery of therapeutic agents to target organs, tissues, and cells. Metallic nanoparticles, such as gold nanoparticles (AuNPs) have exceptional properties which enable efficient drug transport into different cell types with reduced side effects and cytotoxicity to other tissues.Materials and Methods: AuNPs were...