Films of chitosan and N,N,N-trimethylchitosan were cast from aqueous solutions. Chitosan was dissolved in 1% acetic acid while deionized water was the solvent for N,N,N-trimethylchitosan chloride. The resulting films presented different mechanical behaviors as evaluated by DMTA. The film of chitosan exhibited an elastic-type behavior while that of N,N,N-trimethylchitosan was typically viscous. ...

The unique properties and applications of iron oxide and Au nanoparticles have motivated researchers to synthesize and optimize a combined nanocomposite containing both. By using various polymers such as chitosan, some of the problems of classic core-shell structures (such as reduced saturation magnetization and thick coating) have been overcome. In the present study, chitosan and one of its we...

objective(s): an efficient vaccine against tb is an urgent need. tb peptides are safe candidate but they are weak immunogens and needs to be potentiated by adjuvant/delivery systems. the main purpose of the present study was to determine the potential of cht based nps containing esat-6 antigen of m. tuberculosis for inducing mucosal and systemic immune responses after intranasal and subcutaneou...

BACKGROUND & OBJECTIVES With the current snags from the use of Artemisinin - combination therapies (ACTs) in malaria treatment in addition to fear of cross- resistance to unrelated drugs, raising the immunocompetence of individuals in malaria endemic areas by vaccination is the best approach to malaria - free world. METHODS Water - soluble cationic derivative, N, N, N- trimethylchitosan (TMC)...

Development of effective non-viral vectors is of crucial importance in the implementation of RNA interference in clinical routine. The localized delivery of siRNAs to the gastrointestinal mucosa is highly desired but faces specific problems such as the stability in gastric acidity conditions and the presence of the mucus barrier. CDX2 is a transcription factor critical for intestinal differenti...

Superparamagnetic iron oxide nanoparticles with appropriate surface modification can be widely used in various applications including magnetic resonance imaging (MRI) diagnostic contrast agents, anticancer therapy using hyperthermia, magnetic drug targeting, protein and enzyme immobilization, cell labeling and separation or RNA and DNA purification. All these biochemical and biomedical applicat...

Vaccination is considered to be most effective way of fighting infectious diseases like malaria etc [1]. N, N, N-trimethylchitosan (TMC) was synthesized from chitosan. Nanoparticles of the TMC were prepared in various media (milliQ water, Na2CO3 (pH 10.92), Na2HPO4 (pH 9.01) and alhydrogel beads which were characterized as adjuvant for possible vaccine delivery. The nanoparticles were analyzed ...

background: curcumin as a yellow natural compound extracted from turmeric root is known it as an antibacterial agent. one of the nanoparticles ability is to decrease the defects of usual drug delivery systems. chitosan is a low toxic, biodegradable, biocompatible and safe polymer which is used in production of nanoparticles. nanoparticles like chitosan-tripolyphosphate (tpp) are able to increas...

background: chitosan nanoparticles have become of great interest for nanomedicine, biomedical engineering and development of new therapeutic drug release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity. the aim of the present study is to synthesis and optimization of chitosan nanoparticles for industrial and biomedical applicati...

the chitosan nanoparticles used widely as a drug delivery systems recently. in the present study the echis carinataus snake venom loaded chitosan nanoparticles were prepared based on ionic gelation of tripolyphosphate and chitosan. the nanoparticles physicochemical characteristics, stability and biological activity of encapsulated venom were studied. the particles were spherical in shape and th...