نتایج جستجو برای: Chitosan Nanoparticles

تعداد نتایج: 121183  

Journal: :European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2008
Chunqiang Guo Richard A Gemeinhart

Polyelectrolyte-coated nanoparticles or microparticles interact with bioactive molecules (peptides, proteins or nucleic acids) and have been proposed as delivery systems for these molecules. However, the mechanism of adsorption of polyelectrolyte onto particles remains unsolved. In this study, cationic poly(lactide-co-glycolide) (PLGA) nanoparticles were fabricated by adsorption of various conc...

Journal: :iranian journal of biotechnology 2014
reza mirnejad mirza ali mofazzal jahromi sharafaldin al-musawi majid pirestani mahdi fasihi ramandi

background: curcumin as a yellow natural compound extracted from turmeric root is known it as an antibacterial agent. one of the nanoparticles ability is to decrease the defects of usual drug delivery systems. chitosan is a low toxic, biodegradable, biocompatible and safe polymer which is used in production of nanoparticles. nanoparticles like chitosan-tripolyphosphate (tpp) are able to increas...

Journal: :caspian journal of internal medicine 0
arezou ghadi noshirvani university of technology, babol, iran soleiman mahjoub babol university of medical sciences, babol, iran fatemeh tabandeh national institute of genetic engineering and biotechnology (nigeb), tehran, iran farid talebnia noshirvani university of technology, babol, iran

background: chitosan nanoparticles have become of great interest for nanomedicine, biomedical engineering and development of new therapeutic drug release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity. the aim of the present study is to synthesis and optimization of chitosan nanoparticles for industrial and biomedical applicati...

2011
Yu-Lan Hu Wang Qi Feng Han Jian-Zhong Shao Jian-Qing Gao

BACKGROUND Although there are a number of reports regarding the toxicity evaluation of inorganic nanoparticles, knowledge on biodegradable nanomaterials, which have always been considered safe, is still limited. For example, the toxicity of chitosan nanoparticles, one of the most widely used drug/gene delivery vehicles, is largely unknown. In the present study, the zebrafish model was used for ...

2014
Arezou Ghadi Soleiman Mahjoub Fatemeh Tabandeh Farid Talebnia

BACKGROUND Chitosan nanoparticles have become of great interest for nanomedicine, biomedical engineering and development of new therapeutic drug release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity. The aim of the present study was to synthesis and optimize of the chitosan nanoparticles for industrial and biomedical applicati...

2018
Frans Ricardo Tamara Chi Lin Fwu-Long Mi Yi-Cheng Ho

This study attempted to develop chitosan-based nanoparticles with increased stability and antibacterial activity. The chitosan/protamine hybrid nanoparticles were formed based on an ionic gelation method by mixing chitosan with protamine and subsequently cross-linking the mixtures with sodium tripolyphosphate (TPP). The effects of protamine on the chemical structures, physical properties, and a...

Journal: :Carbohydrate research 2004
Lifeng Qi Zirong Xu Xia Jiang Caihong Hu Xiangfei Zou

Chitosan nanoparticles, such as those prepared in this study, may exhibit potential antibacterial activity as their unique character. The purpose of this study was to evaluate the in vitro antibacterial activity of chitosan nanoparticles and copper-loaded nanoparticles against various microorganisms. Chitosan nanoparticles were prepared based on the ionic gelation of chitosan with tripolyphosph...

2011
Dariusz Wawro Luciano Pighinelli

This paper describes a method for preparing chitosan fibers modified with hydroxyapatite (HAp), tricalcium phosphate (β-TCP), and HAp/β-TCP nanoparticles. Fiber-grade chitosan derived from the northern shrimp (Pandalus borealis) and nanoparticles of tricalcium phosphate (β-TCP) and hydroxyapatite (HAp) suspended in a diluted chitosan solution were used in the investigation. Diluted chitosan sol...

Journal: :archives of razi institute 2016
n. pomohammadur dounighi m. mehrabi m.r. avadi h. zolfagharian m. rezayat

the chitosan nanoparticles used widely as a drug delivery systems recently. in the present study the echis carinataus snake venom loaded chitosan nanoparticles were prepared based on ionic gelation of tripolyphosphate and chitosan. the nanoparticles physicochemical characteristics, stability and biological activity of encapsulated venom were studied. the particles were spherical in shape and th...

2013
Subashini Rajaram Rajendran Natham

Chitosan, a natural biodegradable polymer is recommended for development of nanoparticles intended for chronic infection such as tuberculosis. Formulation and processing variables play a critical role in the formation of nanoparticles prepared with chitosan. The present study investigated the influence of polymer (chitosan) molecular weight, stabilizing agent (tween 80) concentration and stirri...

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