in recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. high-performance liquid chromatography is a very useful method for the direct separation of enantiomers. however, about 30−40 years ago, commercially available chiral stationary phases wer...

In recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. High-performance liquid Chromatography is a very useful method for the direct separation of enantiomers. However, about 30−40 years ago, commercially available chiral stationary phases wer...

a method is described by which it is possible to determine the high barrier to ring inversion and hindered rotation by neat racemization of optically active compounds when the racemization is caused by ring inversion or hindered rotation. the method is based preparation of sufficiently pure enantiomers, mainly by chromatography on swollen microcrystalline triacetylcellulose (tac). by this techn...

Since the turn of the twentieth century, it has been recognized that many drugs, agrochemicals, food additives and fragrances are chiral compounds and their chirality may considerably affect their bioactive behavior [1, 2]. The demand has been increasing for new analytical methods with high selectivity and efficiency. Chiral separation has become an attractive and important field in the separat...

the high performance liquid chromatography (hplc) enantioseparation of four β-blocking agents metoprolol, bisoprolol, propranolol and atenolol was performed on amylose tris-(3,5-dimethylphenylcarbamate) chiral stationary phase using n-hexane-ethanol-diethylamine (dea) as the mobile phase and related chiral recognition mechanisms were discussed. enantiomeric separation of the fourβ-blockers was ...

In recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. High-performance liquid Chromatography is a very useful method for the direct separation of enantiomers. However, about 30−40 years ago, commercially available chiral stationary phases wer...

of amino alcohols using Z-L-Glu-L-Pro or Z-L-Glu-D-Pro as chiral counter ions and Hypercarb as the solid phase. Chirality 9: 650}655. Knox JH and Jurand J (1982) Separation of optical isomers by zwitterion pair chromatography. Journal of Chromatography 234: 222}224. Knox JH and Ross P (1997) Carbon-based packing materials for liquid chromatography. Advances in Chromatography, 74}162. Petterson ...

The use of CE in the analysis of pharmaceuticals is now becoming Rrmly established as a useful complement and alternative to the more widely employed technique of HPLC. The major attractions of CE are that considerable cost and time savings are possible, especially in the areas of chiral analysis and in the determination of solutes having limited or no chromophore. The recent advent of the use ...

REVIEWS This review covers developments and applications in chiral separations from January 2000 to March 2002. This review is not intended to be a comprehensive review of all papers published, but focuses on major developments in the field of chiral separations as well as representative applications. The review is restricted to the English language literature except as noted for several specif...

The high performance liquid chromatography (HPLC) enantioseparation of four β-blocking agents metoprolol, bisoprolol, propranolol and atenolol was performed on amylose tris-(3,5-dimethylphenylcarbamate) chiral stationary phase using n-hexane-ethanol-diethylamine (DEA) as the mobile phase and related chiral recognition mechanisms were discussed. Enantiomeric separation of the fourβ-blockers was ...