نتایج جستجو برای: Chimerism

تعداد نتایج: 2215  

Ali Fani, Ali Ghasemi, Hossein Ayatollahi, Maryam Salehi, Maryam Sheikhi, Nafiseh Amini, Payam Siyadat, Sare Etemad,

Background: Bone marrow transplantation (BMT) is considered as a curative therapy for a broad range of diseases. However, complications such as relapse and graft versus host disease (GVHD) may be observed following BMT. Chimerism analysis serves as a reliable indicator of transplant outcome. Complete chimerism refers to the complete replacement of hematopoietic system by donor cells, while mixe...

Background and Objective: The present study investigated the effect of donor stem cells on improving transplant survival and reducing the need to use repressive drugs in patients with kidney transplant. Methods: The clinical trial included two groups of patients. A total of five patients received stem cells prepared from the peripheral blood (18–23 ×109 cells/case) four times befor...

Journal: :Haematologica 2009
Federico Moscardó Jaime Sanz Leonor Senent Susana Cantero Javier de la Rubia Pau Montesinos Dolores Planelles Ignacio Lorenzo Jose Cervera Javier Palau Miguel A Sanz Guillermo F Sanz

BACKGROUND Cord blood transplant is a feasible treatment alternative for adult patients with hematologic malignancies lacking a suitable HLA-matched donor. However, the kinetics of myeloid recovery is slow, and primary graft failure cannot be detected easily early after transplantation. We investigated the impact of hematopoietic chimerism status from unselected marrow cells 14 days after trans...

Journal: :Annals of the rheumatic diseases 2007
Idske C L Kremer Hovinga Marije Koopmans Hans J Baelde Emile de Heer Jan A Bruijn Ingeborg M Bajema

BACKGROUND Chimerism indicates the presence of cells from one individual in another individual, and has been associated with several autoimmune diseases. Although this finding may point towards a role for chimerism in the induction of SLE, it could also indicate that chimerism is the result of repair mechanisms after injury. OBJECTIVE To perform a post-mortem investigation for the presence of...

2016
Sabrina Peters Christian Junghanss Anne Knueppel Hugo Murua Escobar Catrin Roolf Gudrun Knuebel Anett Sekora Iris Lindner Ludwig Jonas Mathias Freund Sandra Lange

BACKGROUND Langerhans cells (LC) are bone marrow-derived cells in the skin. The LC donor/recipient chimerism is assumed to influence the incidence and severity of graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation (HSCT). In nonmyeloablative (NM) HSCT the appearance of acute GVHD is delayed when compared with myeloablative conditioning. Therefore, we examined the dev...

2013
David P. Al-Adra Colin C. Anderson

Mixed chimerism is a promising approach toward generating donor-specific immunological tolerance. However, chimerism induction can be toxic; therefore, there is an effort to develop non-myeloablative, minimal intensity protocols that can generate chimerism without the toxic side effects. Recently, with the goal of creating a minimalistic chimerism induction protocol in the tolerance resistant n...

Journal: :Experimental hematology 2015
Tanja Stahl Manja U Böhme Nicolaus Kröger Boris Fehse

Analysis of hematopoietic chimerism after allogeneic stem cell transplantation represents a crucial method to evaluate donor-cell engraftment. Whereas sensitivity of classical approaches for chimerism monitoring is limited to ≥1%, quantitative polymerase chain reaction (qPCR)-based techniques readily detect one patient cell in >1,000 donor cells, thus facilitating application of chimerism asses...

2011
Fei Xue Wei Chen Xue-Li Bai Guo-Dong Xu Liang Liang Ting-Bo Liang

The accurate diagnosis of acute graft-versus-host disease following liver transplantation (LTx-aGVHD) has been hampered. Chimerism appears in the majority of recipients after LT and its significance in the diagnosis of LTx-aGVHD has not been clearly established. To demonstrate the significance of chimerism on the diagnosis of LTx-aGVHD, we compared the change of chimerism in syngeneic LT recipi...

Journal: :cell journal 0

introduction: monitoring the engraftment of donor cell after allogeneic blood stem cell transplantation is important for the early diagnosis of graft failure or relapse of disease. so analysis of donor chimerism has become a routine method for documentation of engraftment after allogeneic stem cell transplantation. in humans, the amelogenin gene is present on both the x and the y chromosomes. h...

2011
Adriana Plesa Xavier Thomas Quoc Hung Le Anne-Sophie Michallet Valérie Dubois Charles Dumontet Mauricette Michallet

Determination of minimal residual disease (MRD) remains crucial for the follow-up after therapy in chronic lymphocytic leukemia (CLL) patients. Chimerism was assessed by short tandem repeat (STR)PCR and single nucleotide polymorphisms (SNP)PCR, and MRD by a multicolor flow cytometric approach in 12 consecutive patients with CLL after they received allogeneic stem cell transplantation (SCT). Ove...

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