OBJECTIVE: To discuss clinical data on the utility of 2 colony-stimulating factors(CSFs), filgrastim and pegfilgrastim, in reducing the risk and incidence of neu-tropenic complications with chemotherapy. DATA SOURCES: This article reviews the data from the clinical studies for bothpegfilgrastim and filgrastim. Additionally, data from large, population-based ret-rospective analys...

AIM Gastro-splenic fistula is a rare entity in which malignant tumors are the primary cause, followed by perforated peptic ulcers and Crohn's disease. CASE REPORT A 66 years old patient undergoing chemotherapy for gastric large cells B lymphoma presented fever, fatigue and worsening of general conditions. A CT scan showed the presence of an abdominal abscess resulting from a pathological comm...

The NANOMA project aims at the development of a drug delivery microrobotic system (consisting of nanoActuators and nanoSensors) for the propulsion and navigation of ferromagnetic microcapsules in the cardiovascular system through the induction of force from magnetic gradients generated by a clinical Magnetic Resonance Imaging (MRI). The main motivation for the NANOMA project is the early diagno...

Background: One of the side effects of chemotherapy agents is gonadal suppression leading to infertility. The present study examined the feasibility of using a gonadotropin releasing hormone agonist (GnRH-A) in the prevention of busulfan induced azoospermia in prepubertal mice. Materials and Methods: Leuprolide(3.8 mg/kg) was given to prepubertal male mice 2 weeks after or prior to busulfan (40...

We have recently reported (8) a comparative study of the effects of chemotherapeutic agents in spontaneous mammary tumors of mice and in firstand second-generation transplants of these tumors. In these studies Z backcross (ZBC) mice were employed as the recipients for the trans plants. It was found that the growth of the spon taneous tumors per se was not inhibited by four of the five agents wh...

We have recently reported (8) a comparative study of the effects of chemotherapeutic agents in spontaneous mammary tumors of mice and in firstand second-generation transplants of these tumors. In these studies Z backcross (ZBC) mice were employed as the recipients for the trans plants. It was found that the growth of the spon taneous tumors per se was not inhibited by four of the five agents wh...

Tumors constitute complex ecosystems with multiple interactions among neoplastic cells displaying various phenotypes and functions and where the tumoral niche is built with an active participation of the host environment that also impacts the malignant progression of the tumor cells. Irrespective of the cell of origin of prostate adenocarcinoma, mounting evidences support the existence of a hie...

Hycanthone in a single dose of 3.3 mg/kg of body weight was used to treal mansoni schistosomiasis in 597 persons (83%) of the population of the endemic vilage of Canabrava. Ninety two patients received a 2nd course 14 months later. There was one death em the 2nd treatment. The cure rate after one stool examination was smaller after the 2ni treatment in comparison with the first one. Re-infectio...

It is well recognized that many chemotherapeutic agents are inactivated in vivo and may lose a part or all of their antibacterial activities. Davis' 2 has described that this phenomenon is attributed in part to the serum protein binding of the antibacterial agents. After this report, the extensive studies on protein binding of sulfonamids,3 penicillins; 9 tetracyclines10-'2 and other chemothera...

With the advent of multifunctional nano delivery systems, simultaneous imaging and therapy aspires to detect and treat tumors at a very early stage with promising out‐ comes. In this context, numerous anti-cancer drug/gene delivery systems have been ex‐ plored with the primary aim to increase the treatment efficacy without compromising safety. Secondary goals include enhancing bioavailability, ...