Introduction: Chemokine receptors are found on the surface of stem cells. There have been 19 distinct chemokine receptors described in mammals. Chemokines are major players in migration and homing. Therefore, changes in their levels or function can help us to increase the migratory potential of these cells. Valproic acid differs in structure from other drugs in common use. The way in which Va...

introduction: chemokine receptors are found on the surface of stem cells. there have been 19 distinct chemokine receptors described in mammals. chemokines are major players in migration and homing. therefore, changes in their levels or function can help us to increase the migratory potential of these cells. valproic acid differs in structure from other drugs in common use. the way in which valp...

background: chemokine receptors have been shown to play an important role in the development and metastatic spread of various malignancies. in this study, the gene expression profile of some key chemokine receptors involved in metastasis has been investigated in esophageal and breast cancer cell lines.   methods: in a descriptive study, gene expression profile of ccr1, ccr6, ccr7, ccr9, cxcr1, ...

Objective(s): Berberine is one of the main alkaloids and it has been proven to have different pharmacological effects including inhibition of cell cycle and progression of apoptosis in various cancerous cells; however, its effects on cancer metastasis are not well known. Cancer cells obtain the ability to change their chemokine system and convert into metastatic cells. In this study, we examine...

objective(s): berberine is one of the main alkaloids and it has been proven to have different pharmacological effects including inhibition of cell cycle and progression of apoptosis in various cancerous cells; however, its effects on cancer metastasis are not well known. cancer cells obtain the ability to change their chemokine system and convert into metastatic cells. in this study, we examine...

Background: Chemokines are a family of cytokines initially characterized by their capacity to induce chemotaxis, or directed leukocyte migrations. These receptors are activated by chemotactic cytokines called chemokines. Interactions between chemokines and chemokine receptors also are involved in tumorigenesis, migration and invasion of lymphoma cells.Methods: An English literature search...

objective(s):the limited homing potential of bone-marrow-derived mesenchymal stem cells (bm-msc) is the key obstacle in msc-based therapy. it is believed that chemokines and chemokine receptor interactions play key roles in cellular processes associated with migration. meanwhile, mscs express a low level of distinct chemokine receptors and they even lose these receptors on their surface after a...

Objective(s):The limited homing potential of bone-marrow-derived mesenchymal stem cells (BM-MSC) is the key obstacle in MSC-based therapy. It is believed that chemokines and chemokine receptor interactions play key roles in cellular processes associated with migration. Meanwhile, MSCs express a low level of distinct chemokine receptors and they even lose these receptors on their surface after a...

background: despite advances in the medical care of renal transplant recipients which have led to an improvement in allograft survival, renal allograft rejection is still a major ob-stacle to successful organ transplantation. understanding the mechanisms contributing to allograft rejection will be of great importance for the development of efficient antirejection strategies. objective: the aim ...