Drug resistance is a major hurdle in anticancer chemotherapy. Combined therapy using drugs with distinct mechanisms of function may increase anticancer efficacy. We have recently identified the novel chalcone derivative, chalcone-24 (Chal-24), as a potential therapeutic that kills cancer cells through activation of an autophagy-mediated necroptosis pathway. In this report, we investigated if Ch...

T RANSCRIPTION in eukaryotes involves transcriptional activators, proteins that bind to specific sites distal from the TATA box termed enhancers or u p stream activation sequences (UASs) . When bound to a UAS, a transcriptional activator is able to stimulate the transcription initiation complex leading to synthesis of the mRNA. The ability of Saccharomyces cermisiar to use serine or threonine a...

Method: Fifteen nonpregnant gilts obtained from a PRRS-free herd were vaccinated twice with a modified-live PRRSV vaccine prior to artificial insemination. At 90 days of gestation, these VACC-CHAL gilts and 16 pregnant, nonvaccinated CHAL sows were randomly allotted to one of four experimental groups: a control group that received a sham inoculation, or to groups that received a “low” (102 CCID...

The problem of modulating cell fate programs to create distinct patterns and distributions of specialized cell types in different tissues is common to complex multicellular organisms. Here, we describe the previously uncharacterized CHALLAH (CHAL) gene, which acts as a tissue-specific regulator of epidermal pattern in Arabidopsis thaliana. Arabidopsis plants produce stomata, the cellular valves...

the aim of this study was to determine physicochemical, microbial properties and antioxidant activityof fermented camel milk (chal) and introduce it as a functional food. the protein content of thesamples was determined using kjeldahl method and total dry matter using oven drying method. theamount of fat content with gerber method and ph was measured using a ph meter. antioxidantactivity was al...

The aim of this study was to determine physicochemical, microbial properties and antioxidant activity of fermented camel milk (Chal) and introduce it as a functional food. The protein content of the samples was determined using Kjeldahl method and total dry matter using oven drying method. The amount of fat content with Gerber method and pH was measured using a pH meter. Antioxidant activity wa...

Traffic control systems have reached a high level of sophistication: they are general purpose machines that can, in principle, run any traffic control software. The firmware they are running turns them into special purpose machines able to operate only according to some pre-defined rules. The firmware usually allows limited customizations through parameters, but it does not support the introduc...

The species composition of bumblebees (Bombus species) across the elevation gradients in Chitwan-Annapurna Landscape (CHAL) was studied from April to November 2019. We performed opportunistic surveys collect bumblebee specimens. walking transects were followed accessible places along Kaligandaki, Marshyandi, and Budhigandaki river basins different habitats (e.g., agricultural, forest, grassland...

The winds of change sweeping across our globalised world have inspired a wide range studies, new research paradigms, and concepts that seek to characterise their nature effects, the chal...