BACKGROUND: Cervical cancer (CC) is the fourth leading cause of among women in world. Metabolomics can provide a deeper understanding underlying metabolic alterations associated with its pathophysiology. OBJECTIVE: To systematically analyze metabolomic approaches and findings used study cervical cancer. SELECTION CRITERIA: Studies that included use metabolomics, obtained through biological samp...

Cervical cancer (CC) is the third most common cancer in women worldwide; however, CC is a preventable disease, and much effort should be done to prevent it. Persistence of high-risk HPV infection is the strongest epidemiologic risk factor for CC, however it is not sufficient for development of the disease it cofactors should be present. In 2004; IARC listed cervical cancer among those causally ...

Cervical cancer remains an important cause of women morbidity and mortality. The progression of cervical pathology correlates with the HPV integration into the host genome. However, the data on the viral integration status in cervical dysplasias are controversial. The aim of the current study was to evaluate the status of HPV integration in two types of cervical pathology - invasive and non inv...

BACKGROUND To assess the association between MTHFR polymorphism and cervical cancer risk, a meta-analysis was performed. METHODS Based on comprehensive searches of the PubMed, Embase, and Web of Science databases, we identified outcome data from all articles estimating the association between MTHFR polymorphism and cervical cancer risk. The pooled odds ratio (OR) with 95% confidence intervals...

Interleukin-6 (IL-6), a central proinflammatory cytokine, maintains immune homeostasis and also plays important roles in cervical cancer. Therefore, we aimed to evaluate any associations of IL-6 gene polymorphisms at positions -174 and -572 with predisposition to cervical cancer in a Chinese population. The present hospital- based case-control study comprised 518 patients with cervical cancer a...

objective(s):eukaryotic translation initiation factor 4e (eif4e) is overexpressed in cervical cancer (cc). however, the molecular mechanisms are unclear. this study aimed to investigate the molecular mechanism of eif4e gene overexpression in cc. materials andmethods:the human papillomavirus (hpv) type 18 e7 and eif4e mrnas were measured following knock down or overexpression of e7 gene by rt-pc...

Abstract This chapter focuses on the role of imaging, in particular magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET), for evaluation patients with cervical cancer (CC) endometrial (EC).

Human papillomavirus (HPV) can activate Toll-like receptor (TLR)/nitric oxide (NO) signaling pathways; however, whether the TLR/NO pathway is involved in cervical cancer caused by high-risk HPV (HR-HPV) remains unclear. In this study, 43 HR-HPV-positive patients with cervical cancer (CC group), 39 HR-HPV-positive patients with a healthy cervix (HR-HPV group), and 33 HR-HPV-negative controls wer...

Cervical cancer (CC) is the fourth most common cause of death among women globally. Nearly 90% CC mortality occurs in low- and middle-income countries. Hence there an urgent need for identification new biomarkers early diagnosis treatment CC. Current research aims to investigate effect mechanism estrogen receptor 1 aurora kinase A as potential diagnostic cervical cancer. Gene microarray dataset...

Radiotherapy combined with platinum-based chemotherapy is the standard-of-care of locally advanced cervical cancer (CC) patients, while nearly 50% of patients do not respond to standard chemotherapy. Thus, identification of relative molecules participated in chemotherapy might provide new insights in the treatment of CC. In this study, we found a cohort of miRNAs were dysregulated upon treatmen...