Background: Nitric oxide synthase (NOS) activity is increased during hypertension and cerebral ischemia. NOS inactivation reduces stroke-induced cerebral injuries, but little is known about its role in blood-brain barrier (BBB) disruption and cerebral edema formation during stroke in acute hypertension. Here, we investigated the role of NOS inhibition in progression of edema formation and BBB d...

introduction: extreme altitude travel has gained popularity globally for adventurous, scientific, and military endeavors. cerebral venous sinus thrombosis (cvst) at extreme altitude is a rare, covert, and emergent condition requiring immediate intervention. case presentation: a case of cvst masqueraded as high altitude cerebral edema (hace) at 6700 m/22000 ft in karakoram himalayas. atypical ol...

background: nitric oxide synthase (nos) activity is increased during hypertension and cerebral ischemia. nos inactivation reduces stroke-induced cerebral injuries, but little is known about its role in blood-brain barrier (bbb) disruption and cerebral edema formation during stroke in acute hypertension. here, we investigated the role of nos inhibition in progression of edema formation and bbb d...

a 34 day-old girl infant was admitted for poor feeding and cholestasis. she had a bulging fontanelle, with no evidence of intracranial infection or hemorrhage. investigations demonstrated that she had galactosemia. computed tomographic scans demonstrated the presence of diffuse cerebral edema. after treatment the edema resolved.

massive cerebral infarction is often accompanied by early death, secondary to brain edema and trans-tentorial herniation. several reports indicate beneficial effects of decompressive craniectomy in this situation, but the efficacy of this procedure is still a matter of debate. a n experimental study in a period of3 years was done on2 3 patients with brain edema due to massive cerebral infarctio...

Background: Angiotensin II (Ang II) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. This study evaluated the role of central Ang II by using candesartan, as an AT1 receptor blocker, in the brain edema formation and blood-brain barrier (BBB) disruption caused by ischemia/reperfusion (I/R) injuries in rat. Methods...

pervious studies have shown that pentoxifylline (ptx) has beneficial effects in reduction of stroke and brain trauma injuries in experimental animals. however, there is very little and controversial information about the effect of ptx on brain edema in cerebral ischemia. therefore, the aim of this study was to determine the effects of different doses of ptx on brain edema and neurological motor...

background: central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. our previous work showed that inhibition of angiotensin converting enzyme (ace) activity prior to induction of ischemia protected the brain from severe ischemia/reperfusion (i/r) injuries. this study evaluated the impacts of post-ischemic inhibition of ace, enalapril, on brain inf...

background & objectives: ischemic stroke is the third leading cause of death and disability in most of the human societies. there is no effective treatment due to complexity of the pathophysiological mechanisms. today, more researches are designed to introduce involving factors and new treatment strategies in brain ischemia. the objective of this study is to introduce an experimental model of t...

background: angiotensin ii (ang ii) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. this study evaluated the role of central ang ii by using candesartan, as an at1 receptor blocker, in the brain edema formation and blood-brain barrier (bbb) disruption caused by ischemia/reperfusion (i/r) injuries in rat. methods...