Hemangioma, which is a rife benign proliferative lesion with vascular tissue origin, is the most common vascular anomaly of infancy. Cellular hemangioma is one type of these tumors, known as the vascular channel formation of endothelial cells. This report describes a 34-year old man with an exophytic lesion on the lower lip , firm, dome shape ,smooth surface with mild keratosis who came to us  ...

We describe a case of 2-month-old girl presented with more than 60 papules and nodules hemangiomas involving the skin sclera, endocanthion, lower lip, labium majus pudenda without visceral laboratory abnormality. A biopsy showed numerous scattered, clearly limited, irregular cellular lobules in dermis circumvoluted into capillaries comprising incomplete vessel walls, which was consistent diagno...

A rare presentation of an oral hemangioma in a 3month-old child is reported. The lesion was gray, began central in bone, and expanded rapidly into the oral cavity. The hemangioma is a tumor of mesenchymal origin. It is found occasionally in the oral cavity. The cellular hemangioma is one of a family of tumors characterized by the formation of vascular tubes of endothelial cells. The tumors are ...

Infantile hemangioma (IH) is the most common tumor of infancy. Its cellular origin and biological signals for uncontrolled growth are poorly understood, and specific pharmacological treatment is unavailable. To understand the process of hemangioma-genesis we characterized the progenitor hemangioma-derived stem cell (HemSC) and its lineage and non-lineage derivatives. For this purpose we perform...

Infantile hemangioma is a benign endothelial tumor composed of disorganized blood vessels. It exhibits a unique life cycle of rapid postnatal growth followed by slow regression to a fibrofatty residuum. Here, we have reported the isolation of multipotential stem cells from hemangioma tissue that give rise to hemangioma-like lesions in immunodeficient mice. Cells were isolated based on expressio...

Infantile hemangioma, a common benign tumor of infancy, grows quickly in the first year of life, and then regresses slowly to fibrofatty tissue in childhood. The accumulation of fibrofatty tissue in hemangioma involution indicates adipogenesis during this period. Perivascular cells (PCs) from multiple organs display multi-lineage differentiation, including adipogenesis. So we supposed that PCs ...

Infantile hemangiomas are endothelial tumors that grow rapidly in the first year of life and regress slowly during early childhood. Although hemangiomas are well-known vascular lesions, little is known about the mechanisms that cause the excessive endothelial cell proliferation in these most common tumors of infancy. To investigate the molecular basis of hemangioma, we isolated endothelial cell...