This paper deals with the cellular manufacturing system (CMS) that is based on group technology concepts. CMS is defined as identifying the similar parts that are processed on the same machines and then grouping them as a cell. The most proposed models for solving CMS are focused on cell formation problem while machine layout is considered in few papers. This paper addresses a mathematical mo...

This paper presents a novel, multi-objective mixed-integer nonlinear programming (MINLP) model for a cell formation problem (CFP) with alternative means. Due to existing contradiction among objectives, three are considered: 1) Minimizing the total cost consisting of; intercellular movements, purchasing, operation, and maintenance; 2) maximizing the utilization of machines in the system; 3) mini...

In the present study, the operating conditions of an anode-supported high temperature direct internal reforming (DIR) planar solid oxide fuel cell (SOFC) are numerically analyzed. SOFCs are the energy conversion devices that produce electricity and heat directly from a gaseous fuel by the electrochemical combination of that fuel with an oxidant. A planar SOFC consists of an interconnect structu...

objectives: graft versus host disease (gvhd) is a life threatening reaction in the stem cell transplantation process. nowadays cyclosporine is the most commonly utilized agent for gvhd prophylaxis and it has a major role in successful transplantation. cyclosporine has been applied for many years in this field but it could be stated that currently no general consensus is available for its optima...

This paper presents the idea of creating cells while reducing part-level sequence-dependent setup time in general cellular manufacturing systems (CMS). Setup time reduction in CMS has gained modest attention in the literature. This could be attributed to the fact that the fundamental problem in cell formation in CMS has been mainly related to material handling and machine utilization while setu...

human granulocyte-colony stimulating factor (hg-csf) cdna was expressed in the methylotrophic yeast pichia pastoris under the control of the alcohol oxidase (aox1) promoter. an expression vector for hg-csf secretion was constructed using vector ppic9. higher levels of hg-csf was obtained using a p. pastoris mut+ (methanol utilization fast) phenotype. the effects of environmental factors such as...