Human cytochrome P450 (CYP) 2A6 participates in the metabolism of nicotine and precarcinogens, thus the deliberate inhibition of CYP2A6 may reduce cigarette consumption and therefore reduce the risk of developing the types of cancer associated with smoking. The inhibitory effects and mechanisms of celery (Apium graveolens) extract on mouse CYP2A5 and human CYP2A6 activity remain unclear. These ...

Apium graveolens (celery) is an edible and traditionally medicinal plant that is used worldwide, among others for the treatment of hypertension. Combining celery with antihypertensive drugs can affect the pharmacodynamics and pharmacokinetics of the latter drugs. The aim of the study is to assess the effects of administrating the celery extract on captopril pharmacokinetics. Sprague-Dawley stra...

objectives:hypertension is one of the most common diseases of the modern era. this study evaluates the effect of hydro-alcoholic celery leaf extract onsystolic blood pressure (sbp), heart rate (hr) and lipid profile in animals’ model of hypertension induced by fructose. materials and methods: sprague dawley rats were divided into five groups: 1) control group (free access to tap drinking water)...

BACKGROUND Use of medicinal plants with high antioxidant properties could be effective to increase fertility and improvement of disorders such as hormonal imbalance, impotency, oligospermia and immotile sperm. Celery (Apium graveolens) is rich in antioxidant agents. The leaf and stems of celery contain phenols, furanocoumarin and luteolin. Apigenin is one of the main flavonoids of celery leaf. ...

OBJECTIVES Hypertension is one of the most common diseases of the modern era. This study evaluates the effect of hydro-alcoholic celery leaf extract onsystolic blood pressure (SBP), heart rate (HR) and lipid profile in animals' model of hypertension induced by fructose. MATERIALS AND METHODS Sprague Dawley rats were divided into five groups: 1) control group (free access to tap drinking water...

Background and objectives: Apium graveolens L. (celery) has been considered as sedative, analgesic, carminative, antispasmodic and diuretic plant in traditional Iranian medicine. The aim of the present study was to evaluate the anti-nociceptive and anti-inflammatory effect of celery root in mice. Methods: Analgesic effect of celery root was de...

Background and objectives: Pain is an unpleasant feeling which affects the quality of life and relieving from pain is an important goal in many treatment protocols. Apium graveolens L. (celery) has been considered as sedative, analgesic, carminative, antispasmodic and diuretic in Iranian traditional medicine. The aim of present study was to evaluate the anti-n...

Celery (Apium graveolens L.) is a plant species in the family Apiaceae, which has been used in traditional medicine for the treatment of gastrointestinal diseases. This study investigated the effects of aqueous and ethanol extracts from celery leaves on intestinal contractility. Air-dried and powdered leaves were extracted with distilled water and 96% ethanol, respectively. The activities of th...

background use of medicinal plants with high antioxidant properties could be effective to increase fertility and improvement of disorders such as hormonal imbalance, impotency, oligospermia and immotile sperm. celery (apium graveolens) is rich in antioxidant agents. the leaf and stems of celery contain phenols, furanocoumarin and luteolin. apigenin is one of the main flavonoids of celery leaf. ...

BACKGROUND AND OBJECTIVE: Pulmonary fibrosis is one of the most common side effects of bleomycin which is used as a chemotherapeutic agent. Reactive oxygen species play a key role in the development of pulmonary fibrosis. Celery seed contains a variety of flavonoids which are considered as asantioxidants. This study investigated the effects of celery seed hydroalcoholic extract on bleomycin-ind...