The binding interaction of novel podophyllotoxin derivative, (3R,4R)-4-((benzo[d][1,3]dioxol-5-yl)methyl)-dihydro-3-(hydroxy(3,4-dimethoxyphenyl) methyl) furan-2(3H)-one (PPT), with calf thymus DNA (ctDNA) has been examined using UV-Visible absorption spectrophotometry, fluorescence spectroscopy, viscosity measurement and molecular docking studies. UV-Vis absorption results showed hyperchromic ...

The efficiency of an online motion planning algorithm often is measured by a constant competitive factor C. Competitivity means, that the cost of an Ccompetitive online strategy with incomplete information is only C times worse than the optimal offline solution with full information. If a strategy is represented by an infinite sequence X = f1, f2, . . ., the problem of finding a strategy with m...

introduction: today the prevalence of teeth decays has considerably decreased. related organizations and institutions mention several reasons for it such as improvement of decay diagnostic equipment and tools which are even capable of detecting caries in their initial stages. this resulted in reduction of costs for patients and remarkable increase in teeth life span. there are many methods for ...

We consider the problem of scheduling a maximum profit selection of equal length jobs on m identical machines. Jobs arrive online over time and the goal is to determine a non-preemptive schedule which maximizes the total profit of the scheduled jobs. Let the common processing requirement of the jobs be p > 0. For each job ji, i = 1, . . . , n we are given a release time ri (at which the job bec...

background: among diverse protein purification systems, affinity chromatography is the most attractive one in the purification process of coagulation factors. coagulation factor vii is a plasma serine protease that has a significant role in natural human hemostasis and its recombinant form such as aryoseventm, has been applied in clinical treatment of bleeding disorders. immunoaffinity chromato...

Protein aggregation is phenomenon wherein protein loses its native structure and aggregates due to the adaption of non-native conformation. Amyloid aggregation formed by the accumulation of various proteins causes many diseases in humans and other organisms. Antioxidants can prevent proteins aggregation. Pulicaria undulata  extract along with phenolic compounds can increase protein stability an...

a rapid and sensitive hplc method has been developed for the quantification of mirtazapine (mrz), a noradrenergic and specific serotonergic inhibitor antidepressant (nassa) and its two major metabolites n-desmethylmirtazapine (ndm) and 8-hydroxymirtazapine (8-ohm) in human plasma. the separation was achieved using chromolith c18 column and a mobile phase of acetonitrile: phosphate buffer (ph=3,...