The dual culture of Trichoderma harzianum and Catharanthus roseus callus produced an antimicrobial compound with a remarkable activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis. Structural elucidation revealed that this compound, which we have named trichosetin, is a novel tetramic acid (2,4-pyrrolidinedione) antibiotic and a homolog of the fungal metabolite...

background & aim: investigation of suspension cell culture and callus production in catharanthus roseus. catharanthus roseus is an herbaceous perennial plant belongs to the family apocynaceae. c. roseus is important as commercial medicinal plant because of its alkaloidal content. whole plant contains about 130 alkaloids those are classified as vinca alkaloids. vincristine and vinblastine; t...

For biotransformational studies, Callus of Catharanthus roseus was produced from young shoot tip on Murashige & Skoog medium supplemented with 1.5 mg/litre 2, 4-D and 0.5 mg/litre Kin, solidified by 8 g/litre agar at 25±1°C under complete darkness. The cultures were maintained on the same medium at 25±1 °C in the dark by subculturing after every four weeks. Suspension culture of the plant was p...

Background & Aim: Investigation of suspension cell culture and callus production in Catharanthus roseus. Catharanthus roseus is an herbaceous perennial plant belongs to the family Apocynaceae. C. roseus is important as commercial medicinal plant because of its alkaloidal content. Whole plant contains about 130 alkaloids those are classified as vinca alkaloids...

free radicals play an important role in pathological processes such as aging and developing cancer; hence, natural products inhibit free radical production, and can play an important role in preventing diseases. we aimed to evaluate the scavenging activity of free radicals, reducing power, inhibition of lipid peroxidation and malondialdehyde (mda) formation, and the antioxidant composition of r...

Background & Aim: Investigation of suspension cell culture and callus production in Catharanthus roseus. Catharanthus roseus is an herbaceous perennial plant belongs to the family Apocynaceae. C. roseus is important as commercial medicinal plant because of its alkaloidal content. Whole plant contains about 130 alkaloids those are classified as vinca alkaloids...

catharanthus roseus is a medicinal and ornamental plant with growing attention toward its economical value. cell suspension from c. roseus were treated with 0 to 60mm of cadmium nitrate for 1, 3 and 6 days, then cell viability was determined using trypan blue and mtt assay. cell morphology was investigated using 0, 10, 30 and 50 mm of cadmium nitrate as selected dose for 3 days. callus of c.ros...

Catharanthus roseus is a medicinal herb found in many tropical and subtropical regions around the world. This plant produces a diverse array of secondary metabolites that are pharmaceutically important like vinblastine and vincristine used as chemotherapeutic agents in the treatment of several types of cancers. Low yield of these vinca alkaloids from the plant in vivo and the challenges to meet...

Catharanthus roseus is well known for its pharmacological significance. The present study aims to determine the antifungal activity of Catharanthus roseus against various clinically significant fungal strains (Candida albicans, Aspergillus fumigatus, Aspergillus niger, Fusarium moniliforme). Assessment of antifungal activity of Catharanthus roseus was done by paper disc diffusion method. In thi...

Free radicals play an important role in pathological processes such as aging and developing cancer; hence, natural products inhibit free radical production, and can play an important role in preventing diseases. We aimed to evaluate the scavenging activity of free radicals, reducing power, inhibition of lipid peroxidation and malondialdehyde (MDA) formation, and the antioxidant composition of r...