Microglia activation and associated inflammatory response play pivotal roles in the pathogenesis of different neurodegenerative diseases including neonatal hypoxic brain injury. Here we show that caspase3 expression was upregulated in activated microglia after hypoxic exposure, and remarkably, the cell viability remained unaffected alluding to the possibility of a non-apoptotic role of caspase3...

Background: Buceng {combination of pasak bumi (Eurycoma longifolia Jack) and purwoceng (Pimpinella alpine Molk)} has been proven to increase testosterone (Te) level and decrease apoptosis. Unfortunately, there is no evidence whether these effects are mediated by the declining of caspase3. Objective of this study was to evaluate whether buceng could decrease the expression of caspase3 of penis a...

AIMS The aim of the present study was to observe changes in the temporomandibular joint (TMJ) of rats that had been subjected to chronic sleep restriction and to investigate whether Akt, Bad and Caspase3 play a role in the mechanism underlying the changes. MAIN METHODS One hundred and eighty male Wistar rats were randomly divided into three groups (n = 60 in each): cage control group, large-p...

PURPOSE To analyse the relationship between the expression of TNFα and the characteristics of glioma cell line U251. METHODS U251 cell line was transfected with overexpressed TNFα or depleted TNFα constructs. The cell viability, proliferation and apoptosis were determined with MTT assay and flow cytometry analysis. The expressions of TNFα, caspase or microRNA (miR) were detected by Western bl...

Little is known about the respective contributions of cell proliferation and cell death to the control of vertebrate forebrain growth. The homeodomain containing gene barhl2 is expressed in the diencephalon of Xenopus, zebrafish, and mouse embryos, and we previously showed that its over-expression in Xenopus neuroepithelial cells induces Caspase3-dependent apoptosis. These findings suggested th...

Little is known about the respective contributions of cell proliferation and cell death to the control of vertebrate forebrain growth. The homeodomain containing gene barhl2 is expressed in the diencephalon of Xenopus, zebrafish, and mouse embryos, and we previously showed that its over-expression in Xenopus neuroepithelial cells induces Caspase3-dependent apoptosis. These findings suggested th...

OBJECTIVE The mechanism of spinal cord injury has been thought to be related to the vulnerability of spinal motor neuron cells to ischemia. However, the mechanisms of such vulnerability are not fully understood. We previously reported that spinal motor neurons might be lost as a result of programmed cell death and investigated a possible mechanism of neuronal death by means of immunohistochemic...

Little is known about the respective contributions of cell proliferation and cell death to the control of vertebrate forebrain growth. The homeodomain containing gene barhl2 is expressed in the diencephalon of Xenopus, zebrafish, and mouse embryos, and we previously showed that its over-expression in Xenopus neuroepithelial cells induces Caspase3-dependent apoptosis. These findings suggested th...

The mitochondrion plays an important role in myocardial ischemia/reperfusion (MI/R) injury. Osthole, a bioactive coumarin derivative extracted from medicinal plants, has been shown to have protective properties in ischemic disease. The aims of the present study were to explore whether Osthole could attenuate myocardial I/R injury and to investigate the potential mechanisms involved. The I/R mod...

Little is known about the respective contributions of cell proliferation and cell death to the control of vertebrate forebrain growth. The homeodomain containing gene barhl2 is expressed in the diencephalon of Xenopus, zebrafish, and mouse embryos, and we previously showed that its over-expression in Xenopus neuroepithelial cells induces Caspase3-dependent apoptosis. These findings suggested th...