The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin factor-1 (IGF-1) genes in oocytes cultured vitro with optimum elevated doses amphiregulin (50 ng 150 ng), neuregulin-1 (25 ng) tumor necrosis factor-α during maturation based on results effects AREG or NRG-1 TNF-α concentration which caused significant effect, ...

Peptic ulcer disease (PUD) is when gastric mucosa gets injured due to the increase of acid and pepsin enzyme. The common risk factors are infection Helicobacter pylori bacteria misused NSAIDs. This review article aims describe role caspase in PUD. Methods used selection articles PubMed. Caspase a protease enzyme that plays an apoptotic inflammatory reaction can be activated dimerized or cleaved...

Hexameric hemoprotein (HTHP) is employed as a scaffold protein for the supramolecular assembly and activation of apoptotic signalling enzyme caspase-9, using short DNA elements modular recruitment domains. Caspase-9 on HTHP platform due to enhanced proximity followed by combinatorial inhibition at high concentrations. The domains allow reversible switching caspase-9 activity state modulatory st...

Objective(s):  Apoptosis is a tightly regulated process and plays a crucial role in autoimmune diseases. Because abnormalities in apoptosis are considered to be involved in the pathogenesis of systemic lupus erythematosus (SLE), in present study we studied the apoptosis in T lymphocytes from Iranian SLE patientsat protein and gene expression levels for some molecules which are involved in apopt...

Elephantopus scaber Linn. was used traditionally for treating various diseases. Previous studies found the cytotoxicity of this herb against different cell lines. This study aimed to determine the effectiveness of the ethanolic extract of E.scaber in inducing apoptosis by observing itseffect on caspase cascade. This ethanolic extract was obtained by maceration method using 96% ethanol. It was f...

objective(s):  apoptosis is a tightly regulated process and plays a crucial role in autoimmune diseases. because abnormalities in apoptosis are considered to be involved in the pathogenesis of systemic lupus erythematosus (sle), in present study we studied the apoptosis in t lymphocytes from iranian sle patientsat protein and gene expression levels for some molecules which are involved in apopt...

background: metformin is used to lower blood sugar in patients with type ii diabetes. recent research showed that metformin has effects on cancer cell growth. studies show that metformin can induce apoptosis in certain cancer cell lines. in this study, we examined the effect of metformin on apoptosis in the t47d breast cancer cell line. methods : the t47d breast cancer cell line was selected an...