Carvone is a monoterpene that is present in spearmint (Mentha spicata) and caraway (Carum carvi) essential oils and has been shown to have anticonvulsant effects, likely through the blockade of voltage-gated sodium channels, and anxiolytic-like effects. Considering that some anticonvulsants that blocked voltage-gated sodium channels (e.g., sodium valproate and carbamazepine) exert clinical anti...

The aim of the study was to investigate the effect of non-allergenic structural analogues on the sensitizing potential of carvone, a fragrance allergen. The possibility that one molecule might inhibit the allergenic activity of another molecule has been debated for 25 years. The Research Institute for Fragrance Materials states that the sensitizing activity from certain fragrance aldehydes is "...

Response accuracy and odor-sampling times were used to compare the ability of mice to detect (+)-carvone and (+)-terpinen-4-ol and to discriminate between enantiomers of carvone and of terpinen-4-ol. Except for increased odor sampling when mice were first exposed to the (+)-carvone odor, there was no difference in odor-sampling time or response accuracy in tests of odor detection or in discrimi...

We have previously reported a reduction of sensitization to carvone in guinea pigs when adding non-allergenic, structurally related compounds simultaneously at induction. This study investigates the criteria needed to obtain a reduction of sensitization in contact allergy. Linalool, a non-sensitizer structurally unrelated to carvone, significantly reduced the sensitizing capacity of carvone in ...

Whereas the compound formerly known as carvone hydrosulphide is, in fact, dicarvone sulphide [1], the genuine hydrosulphide, (—)-3-mercaptodihydrocarvone, has now been prepared by the addition of hydrogen sulphide to (—)-carvone in the presence of a base following a procedure analogous to that of van Tamelen and Grant [2]. Tt had boiling point 150-151 °/0.5 mm, ri&, 1.5221 [a]2i? —6.3° (c = 4 i...

An atomistic calculation of the interaction between peptide motifs and enantiomeric odorant molecules (carvone and camphor) is performed. The peptide motifs are mimics of segments of the helical receptor structure. The model shows that the enantiomers of carvone have distinctly different interaction profile with all peptides considered, but the enantiomers of camphor do not exhibit any signific...

Limonene is the main constituent of citrus oils whose oxidation produces a set fine chemical compounds such as carvone, carveol, and limonene 1,2-epoxide. This contribution reports results experimental evaluation computational simulation carvone separation by fractional distillation from reaction mixture. Carvone was obtained over perchlorinated iron phthalocyanine supported on modified silica ...

The optical rotatory dispersion (ORD) and circular dichroism of the conformationally flexible carvone molecule has been investigated in 17 solvents and compared with results from calculations for the "free" (gas phase) molecule. The G3 method was used to determine the relative energies of the six conformers. The optical rotation of (R)-(-)-carvone at 589 nm was calculated using coupled cluster ...

Adsorption and desorption of volatile organic compounds (VOCs) on indoor material surfaces can impact VOC concentrations in air. In this study, we investigate the adsorption kinetics limonene one its oxidation products, carvone, at 297 ± 1 K using situ Fourier transform infrared (FTIR) spectroscopy. particular, carvone two model indoor-relevant surfaces, TiO2 (a component paint self-cleaning su...