Trimethylamine N-oxide (TMAO), a gut-related metabolite, is associated with heart failure (HF) outcomes. However, TMAO the final product of complex metabolic pathway (ie, choline/carnitine) that has never been entirely investigated in HF. The present study investigates panel metabolites involved TMAO-choline/carnitine for their associations outcome acute HF patients. In total, 806 plasma sample...

background: l-carnitine has been demonstrated to confer cardiac protection against ischemia reperfusion injury in animals. this study evaluates the effects of l-carnitine administration on cardiac biomarkers after coronary artery bypass graft (cabg) surgery. methods: one hundred thirty-four patients undergoing elective cabg surgery, without a history of myocardial ischemia or previous l-carniti...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : previous reports have suggested acute phase proteins, such as albumin, to alter in hemodialysis (hd) patients. intravenous l-carnitine supplementation is expected to improve the level of plasma albumin in hd patients. this study was performed to evaluate the effects of oral l-carnitine supplementation on hemog...

Abstract Primary carnitine deficiency (PCD) can be lethal. Carnitine is essential for the transfer of long‐chain fatty acids across inner mitochondrial membrane β‐oxidation. The reported prevalence PCD in Faroe Islands 1:300 highest world. Faroese patient cohort has been closely monitored and we now report results from a 10‐year follow‐up study 139 patients. Four patients have died natural caus...

Mersalyl inhibited the respiration of heart mitochondria under conditions that required the transport of (-)-carnitine and acyl(-)-carnitines. The exchange of external carnitine and acylcarnitines for intramitochondrial carnitine was also inhibited by mersalyl and 1 mM mersalyl proved suitable for the inhibitor-stop assay of carnitine acylcarnitine translocase. The carnitine-carnitine and (-)-c...

background and aim: in skeletal muscle, carnitine plays an essential role in the translocation of long-chain fatty-acids into the mitochondrial matrix for subsequent beta-oxidation. despite an abundance of literature describing the basic mechanisms of action of l-carnitine metabolism, there remains some uncertainty regarding the effects of oral l-carnitine supplementation on metabolism and exer...

background: the physiologic function of carnitine, oxidation of fatty acid and lipid  metabolism, is severely affected in carnitine deficiency, secondary forms of which lead to renal tubular disorders and chronic renal failure. reduction in serum carnitine has been frequently reported in patients and experimental animals treated with antiepileptic drugs, one of which, valproic acid has consiste...

l-carnitine as a water soluble derivative of lysine has a crucial biological role in lipid metabolism. present experiment was conducted to study the effect of l-carnitine supplementation into broiler and/or breeder diets on broilers' performance, blood related factors, carcass characteristics and immune system. l-carnitine was added to the broiler breeder's diets at levels of 0, and 6...

Modulatory effects of l-carnitine, acetate, propionate, and 5-tetradecyloxy-2-furoic acid (TOFA; an inhibitor acetyl-CoA carboxylase) on oxidation esterification [1-14C]-palmitate were studied in hepatocytes isolated from phlorizin-treated control wethers. Our hypotheses that (1) palmitate would be greater sheep injected with phlorizin; (2) l-carnitine increase more (3) acetate propionate decre...

This study aimed to evaluate the rumen protective effectiveness of L-carnitine through in vitro tests, degradation tests and vivo tests. Twelve rumen-fistulated crossbred rams with similar body weights 55±3.6 kg ages 3±0.2 years old were divided into three treatment groups a 3×3 Latin square design, G1 (basal diet no additives), G2 (unprotected L-carnitine) or G3 (rumen-protected L-carnitine). ...