Vinyl carbamate was much more active (10 to 50 times) than ethyl carbamate for the initiation of skin tumors and for the induction of lung adenomas in mice. Vinyl carbamate was also mutagenic to Salmonella typhimurium TA 1535 and TA 100 in the presence of reduced nicotinamide adenine dinucleotide phosphate-fortified rat or mouse liver mitochondrial supernatant fractions. This mutagenic activity...

Abstract Regioselective tritylation and carbonate aminolysis were employed in this work to synthesize cellulose 2,3- bis (3,5-dimethylphenyl carbamate)-6-( α -phenylethyl carbamate)-type chiral selectors. We evaluated optimized the critical aspects of regioselective detritylation at C6 glucopyranose units polysaccharide backbone. The advantage using II comparison I for was analyzed time determi...

Structural modifications of the multipotential carcinogen ethyl carbamate (urethan), CH3CH2—O---CO—-NH2, generally result in dramatic losses of carcinogenic activity, which usually have been assayed by lung adenoma induction and by initiation of skin papillomas in mice (reviewed in Refs. 12 and 20). One exception is ethyl N-hydroxycanbamate, CH3CH2— O—CO—-NHOH, a metabolite of ethyl c...

It has been commonly assumed that carbamate kinnse (EC 2.7.2.2, ATP : carbamate phospllotransferase) catalyzes the transfer of a phosphate group between 1TP and the carbamate ion. Evidence which has been put forward supporting this belief is the observation that freshly dissolved ammonium carbamate is a much better substrate for the enzyme than freshly dissolved ammonium carbonate at pH 9.4 (1)...

Ethyl carbamate and a series of related compounds were given in single intraperitoneal doses to pregnant Syrian hamsters on Day 8 of gestation, and fetuses were examined for malformations on Day 13 of gestation. Urethan produced a variety of malforma tions and growth retardation. Of the compounds modified in the carboethoxy end, n-propyl carbamate was as teratogenic as the ethyl carbamate, and ...

Ethyl carbamate and a series of related compounds were given in single intraperitoneal doses to pregnant Syrian hamsters on Day 8 of gestation, and fetuses were examined for malformations on Day 13 of gestation. Urethan produced a variety of malforma tions and growth retardation. Of the compounds modified in the carboethoxy end, n-propyl carbamate was as teratogenic as the ethyl carbamate, and ...

A series of ruthenium catalysts have been screened under ring-closing metathesis (RCM) conditions to produce five-, six-, and seven-membered carbamate-protected cyclic amines. Many of these catalysts demonstrated excellent RCM activity and yields with as low as 500 ppm catalyst loadings. RCM of the five-membered carbamate series could be run neat, the six-membered carbamate series could be run ...

insect growth regulators and spinosyns which are physiologically and ecologically selective, respectively, have been investigated as replacements or complements to non-selective conventional insecticides. the effects of diflubenzuron, hexaflumuron, profenofos, spinosad and thiodicarb were assessed on the 1st instars of cotton bollworm, helicoverpa armigera (hã¼bner) using dietary and leaf disc ...

New donor building blocks, i.e., triarylamino derivatives, are of great interest for the production organic photovoltaic materials. In this communication, bis(4′-(hexyloxy)-[1,1′-biphenyl]-4-yl)amine was synthesized in a two-step process via hydrolysis its tert-butyl carbamate derivative. tert-Butyl bis(4′-(hexyloxy)-[1,1′-biphenyl]-4-yl)carbamate obtained by Suzuki cross-coupling reaction bis(...

A large group of benzimidazole derivatives are highly effective as an anthelmintics [ 11. Among these, mebendazole (la, methyl 5-benzoylbenzimidazole-2-carbamate) and flubendazole (lb, methyl 5-p-fluorobenzoylbenzimidazole-Z-carbamate) have demonstrated a broad-spectrum of activity against helminth diseases including filarial infections [2-51. In our continuing studies to develop new antifilari...