the aim of this study was to investigate the effect of inflammatory pulpal pain on spatial learning and memory in male wistar rats. fifty-six adult rats were divided into eight groups as follows (n=7 per group): control, sham-operated group that received normal saline, sham vehicle group that received vehicle of capsaicin, three capsaicin treated groups that received intradental injection of 10...

background: cholera is a potentially epidemic and life-threatening secretory diarrhoea characterized by voluminous watery stools, often accompanied by vomiting, and resulting in hypovolemic shock and acidosis. it is caused by certain strains of the species vibrio cholerae which can also cause mild or in apparent infections. the aim of this study is the evaluation of capsaicin, as a potential in...

Introduction: Cognitive impairment is commonly associated with pain. The modulatory role of orexin 1 receptor (OX1R) in pain pathways as well as learning and memory processes is reported in several studies. The current study was designed to investigate the possible role of CA1-hippocampal OX1R on spatial learning and memory of rats following capsaicin-induced orofacial pain. Methods: Orofacial...

Subpopulations of primary nociceptors (C- and Aδ-fibers), express the TRPV1 receptor for heat capsaicin. During cutaneous inflammation, these afferents may become sensitized, leading to hyperalgesia. It is known that TRPV1+ are involved in hyperalgesia; however, their involvement mechanical hyperalgesia unclear. This study explored contribution capsaicin-sensitive development humans following u...

red hot pepper is a plant that belongs to the solanaceae family and is known as capsicum annuum. capsaicin is the active ingredient of cayenne pepper. ghrelin is a hormone, which consists of polypeptide structure. ghrelin also contributes to growth hormone secretion, energy balance, food intake and body weight regulator. the aim of this study was the localization and expression of ghrelin in th...

Introduction: This study aimed to examine the effects of induced inflammatory tooth pain on anxiety level in adult male rats. Methods: The mandibular incisors of 56 adult male rats were cut off and prefabricated crowns were fixed on the teeth. Formalin and capsaicin were injected intradentally to induce inflammatory tooth pain. Diazepam treated group received diazepam 30 minutes...

Capsaicin has general impressive health benefits such as anticancer, stimulates digestion and enables weight loss. The aim of this study is to extract capsaicin from black pepper white by using polar (Ethanol) nonpolar (Acetone) solvents maximize the percentage yield capsaicin. effect temperature solid solvent ratioon investigated for extraction pepper. higher acetone than ethanol both at ratio...

objectives: crocin, a constituent of saffron and yellow gardenia, possesses anti-nociceptive effects. in the present study, we investigated the effects of intra-fourth ventricle injection of crocin in a rat model of orofacial pain. the contribution of opioid system was assessed using intra-fourth ventricle injection of naloxone, an opioid receptor antagonist. materials and methods: a guide cann...

introduction: this study aimed to examine the effects of induced inflammatory tooth pain on anxiety level in adult male rats. methods: the mandibular incisors of 56 adult male rats were cut off and prefabricated crowns were fixed on the teeth. formalin and capsaicin were injected intradentally to induce inflammatory tooth pain. diazepam treated group received diazepam 30 minutes before intraden...

Background: Cholera is a potentially epidemic and life-threatening secretory diarrhoea characterized by voluminous watery stools, often accompanied by vomiting, and resulting in hypovolemic shock and acidosis. It is caused by certain strains of the species Vibrio cholerae which can also cause mild or in apparent infections. The aim of this study is the evaluation of Capsaicin, as a potential in...