BACKGROUND Data on oseltamivir treatment among hospitalized community-acquired pneumonia (CAP) patients are limited. METHODS Patients hospitalized with CAP at 6 hospitals during the 2010-2012 influenza seasons were included. We assessed factors associated with oseltamivir treatment using logistic regression. RESULTS Oseltamivir treatment was provided to 89 of 1627 (5%) children (<18 years) ...

introduction: this study aimed to evaluate the clinical profile and outcomes of adult patients screened and diagnosed with h1n1 influenza infection at a tertiary care hospital in india. materials and methods: this retrospective  study was conducted on all adult patients suspected of h1n1 influenza admitted at a teaching hospital during the epidemic period of january-march 2015. patients were sc...

conclusions a(h1n1)pdm09 viruses, identified in this study in shiraz, iran, contained 5 site specific mutations and were susceptible to oseltamivir. results our results revealed that a(h1n1)pdm09 viruses present in these samples were susceptible to oseltamivir, and contained 5 site specific mutations (v13g, v106i, v241i, n248d, and n369k) in na gene. these mutations correlated with increasing e...

Oseltamivir, a potent and selective inhibitor of influenza A and B virus neuraminidases, is a prodrug that is systemically converted into the active metabolite oseltamivir carboxylate. In light of reported neuropsychiatric events in influenza patients, including some taking oseltamivir, and as part of a full assessment to determine whether oseltamivir could contribute to, or exacerbate, such ev...

AIMS The aims of the present study were to compare the pharmacokinetics of oseltamivir and its active antiviral metabolite oseltamivir carboxylate in obese and non-obese individuals and to determine the effect of obesity on the pharmacokinetic properties of oseltamivir and oseltamivir carboxylate. METHODS The population pharmacokinetic properties of oseltamivir and oseltamivir carboxylate wer...

PURPOSE Oseltamivir is widely used in the treatment and prophylaxis of influenza A and B viral infections. It is ingested as an oral prodrug that is rapidly metabolized by carboxylesterase 1 (CES1) to its active form, oseltamivir carboxylate. Dexamethasone is also used in the treatment of acute respiratory distress syndrome, a severe complication of influenza; however, its influence on the phar...

The oseltamivir has also been recommended in Iran in the annex to the "National Guidelines for novel Coronavirus" and in the prime version of the Flowchart of Diagnosis and Treatment of COVID 19 at the outpatient and inpatient levels .The oseltamivir (Tamiflu) is a neuraminidase inhibitor that blocks the release of flu virus-laden droplets from infected cells in the respiratory tract. The oselt...

Oseltamivir is a potent, well-tolerated antiviral for the treatment and prophylaxis of influenza. Although no relationship with treatment could be demonstrated, recent reports of abnormal behavior in young individuals with influenza who were receiving oseltamivir have generated renewed interest in the central nervous system (CNS) tolerability of oseltamivir. This single-center, open-label study...

Oseltamivir phosphate (Tamiflu), an anti-influenza virus drug, is hydrolyzed by carboxylesterase to an active metabolite. The metabolite inhibits the influenza virus-specific neuraminidase. In this study, the effects of oseltamivir on normal core body temperature were studied in mice. Oseltamivir (30-300 mg/kg, intraperitoneally (i.p.) and 100-1000 mg/kg, orally (p.o.)) dose-dependently lowered...

BACKGROUND Since the novel H7N9 avian influenza outbreak occurred in China in 2013, neuraminidase inhibitors (NAIs) such as oseltamivir and peramivir have been used as first-line drugs to treat the influenza virus infection. This study aimed to compare the efficacy of oseltamivir-peramivir combination therapy versus oseltamivir monotherapy. METHODS A retrospective study of 82 H7N9 confirmed p...