نتایج جستجو برای: CTL Epitope

تعداد نتایج: 26621  

Journal: :Journal of virology 1995
L M Mylin R H Bonneau J D Lippolis S S Tevethia

Simian virus 40 large tumor (T) antigen contains three H-2Db-restricted (I, II/III, and V) and one H-2Kb-restricted (IV) cytotoxic T lymphocyte (CTL) epitopes. We demonstrate that a hierarchy exists among these CTL epitopes, since vigorous CTL responses against epitopes I, II/III, and IV are detected following immunization of H-2b mice with syngeneic, T-antigen-expressing cells. By contrast, a ...

Journal: :iranian journal of immunology 0
zahra meshkat department of virology, faculty of medical sciences, tarbiat modares university, tehran hoorieh soleimanjahi department of virology, faculty of medical sciences, tarbiat modares university, tehran hessam mirshahabi department of virology, faculty of medical sciences, tarbiat modares university, tehran mojtaba meshkat school of medicine, islamic azad university, mashhad maryam kheiandish blood transfusion center, tehran, iran zuhair mohammad hassan department of virology, faculty of medical sciences, tarbiat modares university, tehran

background: vaccines capable of controlling tumor virus based infections are found difficult to develop due to the consistence latent infection in the host. dna vaccines are attractive tools for the development of hpv vaccines and inducing antigen-specific immunity owing to the stability, simplicity of delivery, safety and cost effectiveness. however, there is a need to increase their potency b...

Journal: :Journal of immunology 2003
Beth D Jamieson Otto O Yang Lance Hultin Mary Ann Hausner Patricia Hultin Jose Matud Kevin Kunstman Scott Killian John Altman Kristina Kommander Bette Korber Janis Giorgi Steven Wolinsky

To investigate possible mechanisms behind HIV-1 escape from CTL, we performed detailed longitudinal analysis of Gag (SLYNTVATL)- and RT (ILKEPVHGV)-specific CTL responses and plasma epitope sequences in five individuals. Among those with CTL against consensus epitope sequences, epitope mutations developed over several years, invariably followed by decay of the CTL targeting the consensus epitop...

Alireza Rafiei, Yiukito Kiutade,

CD8+ T cells are thought to play an important role in protective immunity to tuberculosis. The major histocompatibility complex class I subtype HLA-A*0201 is one of the most prevalent class I alleles, with a frequency of over 30% in most populations. HLA-A*0201 transgenic, H-2Db/mouse beta2-microglobulin double-knockout mice (HHD) which express human HLA-A*0201 but no mouse class I, was shown t...

Journal: :Journal of immunology 1999
L M Mylin

SV40 large tumor Ag (Tag) contains four H-2b-restricted (I, II/III, IV, and V) CTL epitopes. A hierarchy exists among these CTL epitopes. CTL directed against epitopes I, II/III, and IV are readily detected following immunization of H-2b mice with SV40, Tag-transformed syngeneic cells, or a vaccinia recombinant that expresses full-length Tag, while epitope V-specific CTL are not. The mechanisms...

Journal: :Journal of immunology 1999
R Wagner B Leschonsky E Harrer C Paulus C Weber B D Walker S Buchbinder H Wolf J R Kalden T Harrer

It has been hypothesized that sequence variation within CTL epitopes leading to immune escape plays a role in the progression of HIV-1 infection. Only very limited data exist that address the influence of biologic characteristics of CTL epitopes on the emergence of immune escape variants and the efficiency of suppression HIV-1 by CTL. In this report, we studied the effects of HIV-1 CTL epitope ...

Journal: :Journal of immunology 1998
G Weidt O Utermöhlen J Heukeshoven F Lehmann-Grube W Deppert

The primary CTL response of BALB/c mice infected with the lymphocytic choriomeningitis (LCM) virus strain WE is directed exclusively against one major epitope, n118, whereas a viral variant, ESC, that does not express n118 induces CTL against minor epitopes. We identified one minor epitope, g283, that induces primary lytic activity in ESC-infected mice. Infections of mice with WE and ESC were u...

Journal: :Journal of immunology 2003
Taeg S Kim Stanley Perlman

CTL escape mutations have been identified in several chronic infections, including mice infected with mouse hepatitis virus strain JHM. One outstanding question in understanding CTL escape is whether a CD8 T cell response to two or more immunodominant CTL epitopes would prevent CTL escape. Although CTL escape at multiple epitopes seems intuitively unlikely, CTL escape at multiple CD8 T cell epi...

2004
G. de Mutsert D. van Baarle D. J. Smith K. Sintnicolaas A.D.M.E. Osterhaus

Recently, an HLA-B*3501-restricted cytotoxic T-lymphocytes (CTL) epitope in the nucleoprotein (NP418–426) of influenza A viruses was identified, which exhibited a high degree of variability. In the present study, the recognition of epitope variants by human cytotoxic Tlymphocytes (CTL) was investigated. Human CD8+ CTL clones were specific for NP418–426 epitope variants within one subtype of inf...

Journal: :Journal of immunology 2003
Otto O Yang Phuong T Nguyen Sarkis Alicja Trocha Spyros A Kalams R Paul Johnson Bruce D Walker

Although CD8(+) CTLs are presumed to be an important mediator of protective immunity in HIV-1 infection, the factors that determine CTL antiviral efficiency are poorly understood. Two factors that have been proposed to influence CTL antiviral function are antigenic avidity and epitope specificity. In this study we evaluate these by examining the activity of HIV-1-specific CTL against acutely in...

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