the aim of this research was to investigate the cyclooxygenase-2 (cox-2) selective inhibition effect on haloperidol-induced catatonia. in this study, the effect of orally, acutely and sub-chronically administrations of compound 11b [1-(phenyl)-5-(4-methylsulfonylphenyl)-2-ethylthioimidazole] (2, 4 and 8 mg/kg), a newly selective cox-2 inhibitor, was investigated against the haloperidol-induced ...

he developed severe psoriasis responsive only to repeated courses of the then newly available PUVA (psoralen plus UVA radiation) therapy. Between 1973 and 1993 he received PUVA once a week. During treatment no genital protection was used although he had never received UV therapy directly to the genital area. Two years after the onset of psoriasis he developed peripheral inflammatory arthritis. ...

Despite the important role of both cyclooxygenase (COX) isoforms (i.e. COX-1 and COX-2) in maintenance of hypersensitivity following peripheral nerve injury, their role in the development of neuropathic pain is not clear. The present study was undertaken to determine the effect of COX inhibitors to address the potential role of COX isozymes in the development of neuropathic pain in rats after c...

A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. According to in-vitro COX-1/COX-2 inhibition data, all compounds (6a-g) were selective inhibitors of COX-2 isoenzyme with IC50 values in the highly potent 0.08-0.16 mM range. These results indicated that both potency and selectivity o...

Despite the important role of both cyclooxygenase (COX) isoforms (i.e. COX-1 and COX-2) in maintenance of hypersensitivity following peripheral nerve injury, their role in the development of neuropathic pain is not clear. The present study was undertaken to determine the effect of COX inhibitors to address the potential role of COX isozymes in the development of neuropathic pain in rats after c...

Objective(s):This study was carried out to investigate the effects of COX-2 selective inhibitor (Celecoxib) or non-selective COX inhibitor (Ibuprofen) on gastrointestinal motility. Materials and Methods: The rats were randomly divided into five groups including: intact, sham, traumatic brain injury (TBI) group (intact rats under TBI), Celecoxib group (10 mg/kg), Ibuprofen group (10 mg/kg). Rats...

A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. According to in-vitro COX-1/COX-2 inhibition data, all compounds (6a-g) were selective inhibitors of COX-2 isoenzyme with IC50 values in the highly potent 0.08-0.16 mM range. These results indicated that both potency and selectivity o...

objective(s):this study was carried out to investigate the effects of cox-2 selective inhibitor (celecoxib) or non-selective cox inhibitor (ibuprofen) on gastrointestinal motility. materials and methods: the rats were randomly divided into five groups including: intact, sham, traumatic brain injury (tbi) group (intact rats under tbi), celecoxib group (10 mg/kg), ibuprofen group (10 mg/kg). rats...