Objective(s): In this study, we aimed to investigate the effects of anti-Fas ribozyme on the apoptosis of T lymphocytes (T cells) in mice model with chronic obstructive pulmonary disease (COPD). Materials and Methods: Male 6-week-old C57BL/6 mice were used to establish the COPD model by exposure to cigarette smoke. The COPD mice were sacrificed for spleen dissection and T cell isolation. T cell...

Cigarette smoke (CS) leads to increased oxidative stress, inflammation, and exaggerated senescence, which are involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). While role cellular senescence COPD is known, it not clear if removal senescent cells could alleviate symptoms. To test this, we used novel mouse model-p16-3MR, studied effect ganciclovir (GCV)-mediated after ...

Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disorder. It often causes weight loss, which considered poor prognostic factor. A Japanese herbal Kampo medicine, Hochuekkito (TJ-41), has been reported to prevent inflammation and loss in COPD patients, but the underlying biological mechanisms remain unknown. In present study, we investigated role of TJ-41 vivo using mouse...

Abstract Chronic obstructive pulmonary disease (COPD) is a worldwide chronic inflammatory lung disease, and influenza A virus (IAV) infection common cause of acute exacerbations COPD (AECOPD). Therefore, targeting viral infections represents promising strategy to prevent the occurrence development flare ups in AECOPD. Jianpiyifei II (JPYFII) traditional herbal medicine used China treat patients...

Introduction: This research was meant to provide a model for COPD diagnosis and to classify the cases into phenotypes; General COPD, Chronic bronchitis, Emphysema, and the Asthmatic COPD using a Bayesian Network (BN). Methods: The model was constructed through developing the Bayesian Network structure and instantiating the parameters for each of the variables. In order to validate the achiev...

Abstract Background Cigarette smoke (CS) is a major risk factor for Chronic Obstructive Pulmonary Disease (COPD). Follistatin-like protein 1 (FSTL1), critical during embryogenesis particularly in respiratory lung development, novel mediator related to inflammation and tissue remodeling. We tried investigate the role of FSTL1 CS-induced autophagy dysregulation, airway Methods Serum specimens wer...

BACKGROUND Chronic obstructive pulmonary disease (COPD) is now recognized as an inflammatory disease and the nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome was speculated to participate into its pathophysiological process, however, a direct role of NLRP3 has yet to be clearly shown. METHOD COPD model was established by tobacco inhalation, COPD modeling and NLRP...

Chronic obstructive pulmonary disease (COPD), which is characterized by airway obstruction, leads to, as the two major forms of COPD, chronic bronchitis and emphysema. This study was conducted to evaluate the effects of herbal formula, PM014, in a murine model of COPD. Balb/c mice were treated once with each herb extract in PM014 or PM014 mixture via an oral injection. Lipopolysaccharide (LPS) ...

Patients with severe COPD are known to have comorbidities such as emaciation, cor pulmonale and right heart failure, muscle weakness, hyperlipemia, diabetes mellitus, osteoporosis, muscle atrophy, arterial sclerosis, hypertension, and depression. Therefore, treatment for COPD needs to focus on these comorbidities as well as the lungs. We previously reported a new mouse model of COPD utilizing t...

Testosterone deficiency is commonly observed in male patients with chronic obstructive pulmonary disease (COPD), which characterized by inflammation of the airways and emphysema. Although clinical trials have indicated that testosterone replacement therapy can improve respiratory function COPD, role pathogenesis COPD remains unclear. The aim this study was to explore effect on development emphy...