We have developed a visualization methodology, called a "cluster overlap distribution map" (CODM), for comparing the clustering results of time series gene expression profiles generated under two different conditions. Although various clustering algorithms for gene expression data have been proposed, there are few effective methods to compare clustering results for different conditions. With CO...

This paper presents a new optimization design methodology that is applicable to modular systems. This new methodology is called concurrent optimization design Ž . method CODM . A modular robot is taken as a case study. The CODM is superior to the existing methods for modular robot configuration design in the sense that traditional type synthesis and dimensional synthesis now can be treated once...

Two homologous 2-oxoglutarate-dependent (ODD) nonheme enzymes thebaine 6-O-demethylase (T6ODM) and codeine-3-O-demethylase (CODM), are involved in the morphine biosynthesis pathway from thebaine, catalyzing O-demethylation reaction with precise regioselectivity at C6 C3 positions of respectively. We investigated origin these by combined molecular dynamics (MD) quantum mechanics/molecular mechan...

medicinal use of the opium poppy (papaver somniferum l) has ancient history, but the isolation of morphine was not described until the early nineteenth century. morphine is the most important alkaloid of opium poppy in the last 50 years. in the morphine pathway has been reported to generate morphine in this species, codm has a crucial role as the gene coding the enzyme responsible for demethyla...

Medicinal use of the opium poppy (Papaver somniferum L) has ancient history, but the isolation of morphine was not described until the early nineteenth century. Morphine is the most important alkaloid of opium poppy in the last 50 years. In the morphine pathway has been reported to generate morphine in this species, CODM has a crucial role as the gene coding the enzyme respons...

Medicinal use of the opium poppy (Papaver somniferum L) has ancient history, but the isolation of morphine was not described until the early nineteenth century. Morphine is the most important alkaloid of opium poppy in the last 50 years. In the morphine pathway has been reported to generate morphine in this species, CODM has a crucial role as the gene coding the enzyme respons...