Abstract Novel DNA nanostructures, locked pseudorotaxane and locked catenane were assembled through topological linkage of a double-stranded target to a circular oligodeoxyribonucleotide (cODN)(+). The formation of these supramolecular complexes occurs with remarkable sequence specificity and is accomplished via local opening of duplex DNA by a pair of homopyrimidine bis-PNAs. The obtained cO...

We present here a novel conjugated aptamer-gold nanoparticle (Apt-AuNPs) fluorescent probe and its application for specific detection of recombinant human erythropoietin-α (rHuEPO-α). In this nanobiosensor, 12 nm AuNPs function as both a nano-scaffold and a nano-quencher (fluorescent energy acceptor), on the surface of which the complementary sequences are linked (as cODN-AuNPs) and pre-hybridi...

DNA is well known to adopt various topological (and pseudotopological) structures like knots, catenanes, Borromean rings, and pseudorotaxanes.[1] It has long been recognized that DNA topology plays a crucial role in such fundamental biological phenomena as DNA supercoiling and topoisomerization.[2] Another reason for the considerable interest in higher order DNA topology structures stems from t...