Abstract Constrained groove pressing (CGP) is one of the severe plastic deformation techniques for sheet metals to impose large strain and produce ultrafine-grained (UFG) structures without any change in dimensions. Cross route-constrained (Cross-CGP), an advanced version conventional CGP process, involves two cycles with equivalent 2.32 per cycle where square sample rotated by 90° after perfor...

In this study, constraint groove pressing (CGP) process and ultrasonic assisted CGP (UCGP) process were investigated on the process forces, mechanical properties of the sheet, including hardness and tensile tests and grain size. Pure copper sheets were used as samples in this research. Samples were tested both with and without ultrasonic vibrations for mechanical properties and grain size up to...

Study of the synthesis of cyanophycin (CGP) in recombinant organisms focused for a long time mostly on the insoluble form of CGP, due to its easy purification and its putative use as a precursor for biodegradable chemicals. Recently, another form of CGP, which, in contrast to the insoluble form, was soluble at neutral pH, became interesting due to its high lysine content, which was also assumed...

This investigation focuses on the development and optimization of cashew gum polysaccharide (CGP) nanoparticles grafted with polypropylene glycol (PPG) as carriers for diclofenac sodium. The parameters affecting formulation was performed using a central composite rotatable design (CCRD). It demonstrated that best achieved when 10 mg CGP mixed μL PPG homogenized at 22,000 rpm 15 min. physicochem...

CGP 28392 is a recently described dihydropyridine derivative with positive inotropic properties. To study the mechanism of action of this putative calcium channel agonist, we have related the effects of CGP 28392 on contraction (measured with an optical video system) and radioactive calcium uptake to ligand-binding studies in cultured, spontaneously beating chick embryo ventricular cells. CGP 2...

Current therapies for renal cell carcinoma have been limited by the unresponsiveness of metastatic disease to conventional treatments. Although the use of biological response modifiers as adjuvant therapy has generally not been successful against disseminated disease, in situ activation of macrophages to a tumoricidal state by liposome-encapsulated immunomodulators has been shown to eradicate m...

Regulators around the world are pushing for a higher representation of females on corporate boards. While this move reduces representation-based gender gap (RGP), less is known how may affect compensation-based (CGP). Using 56,976 director-year observations mandatory quota law imposed in Indian market, we find that significant reduction RGP post-gender period comes at cost substantial increase ...

Recent data suggest that inhibition of the Hedgehog pathway could be a therapeutic target for glioblastoma. Alkaloid cyclopamine inhibits Hedgehog signaling, depleting stem-like cancer cells derived from glioblastoma. However, this compound is toxic for somatic stem cells, preventing its use for clinical applications. In this study, we tested a derivatization product of cyclopamine in the form ...

7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one (CGP-37157) inhibits mitochondrial Na(+)-Ca(2+) exchange. It is often used as an experimental tool for studying the role of the mitochondrial Na(+)-Ca(2+) exchanger in Ca(2+) signaling. Because the selectivity of CGP-37157 in adult cardiomyocytes has not been confirmed, we tested whether CGP-37157 affects the L-type Ca(2+) ch...