نتایج جستجو برای: CFP-10 protein

تعداد نتایج: 2127958  

Journal: :iranian journal of medical sciences 0
atefeh seghatoleslam recombinant protein laboratory, biochemistry department, medical school, shiraz university of medical sciences, shiraz, iran; and histomorphometry and stereology research center, medical school, shiraz university of medical sciences, shiraz, iran mina hemmati recombinant protein laboratory, biochemistry department, medical school, shiraz university of medical sciences, shiraz, iran; and department of biochemistry, faculty of medicine, birjand university of medical sciences, birjand, iran saeedeh ebadat recombinant protein laboratory, biochemistry department, medical school, shiraz university of medical sciences, shiraz, iran; bahram movahedi recombinant protein laboratory, biochemistry department, medical school, shiraz university of medical sciences, shiraz, iran; zohreh mostafavi-pour recombinant protein laboratory, biochemistry department, medical school, shiraz university of medical sciences, shiraz, iran; and maternal-fetal medicine research center, shiraz university of medical sciences, shiraz, iran

background: macrophage immune responses are affected by the secretory proteins of mycobacterium tuberculosis (mtb). this study aimed to examine the immune responses of macrophages to mtb secretory antigens, namely esat-6, cfp-10, and esat-6/cfp-10. methods: thp-1 cells (a human monocytic cell line) were cultured and differentiated to macrophages by phorbol 12-myristate 13-acetate. the cytotoxic...

Journal: :iranian journal of basic medical sciences 0
ali asghar baghani antimicrobial resistance research center, bu-ali research institute, mashhad university of medical sciences, mashhad, iran department of microbiology and virology, school of medicine, mashhad university of medical sciences, mashhad, iran saman soleimanpour antimicrobial resistance research center, bu-ali research institute, mashhad university of medical sciences, mashhad, iran department of microbiology and virology, school of medicine, mashhad university of medical sciences, mashhad, iran hadi farsiani antimicrobial resistance research center, bu-ali research institute, mashhad university of medical sciences, mashhad, iran department of microbiology and virology, school of medicine, mashhad university of medical sciences, mashhad, iran

objective(s): despite treatment with antibiotics and vaccination with bcg, tuberculosis (tb) is still considered as one of the most important public health problems in the world. therefore, designing and producing a more effective vaccine against tb seems urgently. in this study, immunogenicity of a fusion protein which consisting or comprising cfp-10 from mycobacterium tuberculosis and the fc-...

Ali Asghar Baghani, Arman Mosavat, Hadi Farsiani, Hamid Sadeghian Kiarash Ghazvini, Masoud Yousefi Mohammad Reza Akbari Eydgahi, Saeid Amel Jamehdar, Saman Soleimanpour, Seyed Abdolrahim Rezaee Zahra Meshkat

Objective(s): Despite treatment with antibiotics and vaccination with BCG, tuberculosis (TB) is still considered as one of the most important public health problems in the world. Therefore, designing and producing a more effective vaccine against TB seems urgently. In this study, immunogenicity of a fusion protein which consisting or comprising CFP-10 from Mycobacterium tuberculosis and the Fc-...

Journal: :iranian journal of immunology 0
azam torabi department of animal science, faculty of agriculture, ferdowsi university of mashhad mojtaba tahmoorespur department of animal science, faculty of agriculture, ferdowsi university of mashhad fatemeh vahedi razi vaccine and serum research institute, mashhad nader mosavari department of ppd and tuberculin production, razi vaccine and serum research institute, karaj, iran mohammadreza nassiri department of animal science, faculty of agriculture, ferdowsi university of mashhad

background: tuberculosis is a disease with high morbidity, caused mainly by mycobaterium tuberculosis (m.tb.). dna vaccines show a promising future due to their unique advantages over conventional methods. the early-secreted antigen target (esat)-6 and culture filtrate protein (cfp)-10 of m.tb. antigens have been identified as vaccine candidates against mycobacteria and used as subunit vaccines...

Azam Torabi Fatemeh Vahedi, Mohammadreza Nassiri Mojtaba Tahmoorespur Nader Mosavari

Background: Tuberculosis is a disease with high morbidity, caused mainly by Mycobaterium tuberculosis (M.tb.). DNA vaccines show a promising future due to their unique advantages over conventional methods. The early-secreted antigen target (ESAT)-6 and culture filtrate protein (CFP)-10 of M.tb. antigens have been identified as vaccine candidates against Mycobacteria and used as subunit vaccines...

Journal: :Infection and immunity 2004
John S Spencer Hee Jin Kim Angela M Marques Mercedes Gonzalez-Juarerro Monica C B S Lima Varalakshmi D Vissa Richard W Truman Maria Laura Gennaro Sang-Nae Cho Stewart T Cole Patrick J Brennan

Culture filtrate protein 10 (CFP-10) from Mycobacterium tuberculosis is a well-characterized immunodominant 10-kDa protein antigen known to elicit a very potent early gamma interferon response in T cells from M. tuberculosis-infected mice and humans. The sequence of the Mycobacterium leprae homologue of CFP-10 shows only 40% identity (60% homology) at the protein level with M. tuberculosis CFP-...

2017
Ali Asghar Baghani Saman Soleimanpour Hadi Farsiani Arman Mosavat Masoud Yousefi Zahra Meshkat Seyed Abdolrahim Rezaee Saeid Amel Jamehdar Mohammad Reza Akbari Eydgahi Hamid Sadeghian Kiarash Ghazvini

OBJECTIVES Despite treatment with antibiotics and vaccination with BCG, tuberculosis (TB) is still considered as one of the most important public health problems in the world. Therefore, designing and producing a more effective vaccine against TB seems urgently. In this study, immunogenicity of a fusion protein which consisting or comprising CFP-10 from Mycobacterium tuberculosis and the Fc-dom...

Journal: :Journal of bacteriology 2007
Marien I de Jonge Gérard Pehau-Arnaudet Marjan M Fretz Felix Romain Daria Bottai Priscille Brodin Nadine Honoré Gilles Marchal Wim Jiskoot Patrick England Stewart T Cole Roland Brosch

The 6-kDa early secreted antigenic target ESAT-6 and the 10-kDa culture filtrate protein CFP-10 of Mycobacterium tuberculosis are secreted by the ESX-1 system into the host cell and thereby contribute to pathogenicity. Although different studies performed at the organismal and cellular levels have helped to explain ESX-1-associated phenomena, not much is known about how ESAT-6 and CFP-10 contri...

Journal: :Clinical and diagnostic laboratory immunology 2004
W R Waters B J Nonnecke M V Palmer S Robbe-Austermann J P Bannantine J R Stabel D L Whipple J B Payeur D M Estes J E Pitzer F C Minion

Immunological diagnosis of Mycobacterium bovis infection of cattle is often confounded by cross-reactive responses resulting from exposure to other mycobacterial species, especially Mycobacterium avium. Early secretory antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) are dominant gamma interferon (IFN-gamma)-inducing antigens of tuberculous mycobacteria, and they are absent ...

Journal: :Iranian journal of immunology : IJI 2013
Azam Torabi Mojtaba Tahmoorespur Fatemeh Vahedi Nader Mosavari Mohammadreza Nassiri

BACKGROUND Tuberculosis is a disease with high morbidity, caused mainly by Mycobaterium tuberculosis (M.tb.). DNA vaccines show a promising future due to their unique advantages over conventional methods. The early-secreted antigen target (ESAT)-6 and culture filtrate protein (CFP)-10 of M.tb. antigens have been identified as vaccine candidates against Mycobacteria and used as subunit vaccines,...

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