نتایج جستجو برای: CD133 cells
تعداد نتایج: 1384053 فیلتر نتایج به سال:
objective: this study was performed to determine the immunophenotype of megakaryocyte progenitor cells differentiated from ucb cd133+ and cd133− cells under the effects of interleukin–3 (il–3), interleukin–6 (il–6), stem cell factor (scf) and thrombopoietin (tpo) in vitro. materials and methods: cd133+and cd133− cells were isolated by using cd133 isolation kit following the manufacturer’s instr...
Background: The cancer stem cells (CSCs) are involved in invasion and metastasis of melanoma, the most lethal and aggressive form of skin cancer. In the present study, the expression of putative stem cell markers CD133 and ALDH1 were evaluated in melanoma cell lines and then the cells sorted based on the expression of these markers. Methods: In the present study expression of CD133 and A...
Background and Objective: Melanoma is the most deadly type of skin cancer that has a high potency and rapid metastasis to other organs. It appears that cancer stem cells (CSCs) are responsible for invasion and metastasis. The aim of this study was to investigate the expression of cancer stem cells candidate markers and their association with stemness features in mel...
Background: There is evidence that mesangial cell structural changes contribute to the pathogenesis of diabetic nephropathy. To gain better insight into the mechanisms responsible for this issue, present study focused on effect of cord blood mononuclear cells (MNCs) derived CD133 positive cells on mesangial cell structure and function. Materials and Methods: The animals were randomly divided in...
objective: cd133+ umbilical cord blood cells were identified as a hematopoietic stem cell which has the capacity for extensive self-renewal and differentiation. the aim of this study was to identify the effect of staurosporine (sts), a wellknown protein kinase inhibitor on differentiation of cd133+ cells into neural cells. materials and methods: cd133+ cells were enriched by immunomagnetic bead...
microrna modulation during the in vitro culture of hematopoietic stem cells prior to transplantation
background: human umbilical cord blood (hucb) is an acceptable and readily accessible source of stem cells. there is an ongoing interest in cord blood stem cell therapies; however, little is known about the possible unfavorable effects of laboratory modifications on the isolated hucb cells. the involvement of mirnas in several biological processes has been shown. the aim of this study was to ev...
background: there is evidence that mesangial cell structural changes contribute to the pathogenesis of diabetic nephropathy. to gain better insight into the mechanisms responsible for this issue, present study focused on effect of cord blood mononuclear cells (mncs) derived cd133 positive cells on mesangial cell structure and function. materials and methods: the animals were randomly divided in...
background the aim of this study was the ex vivo expansion of umbilical cord blood hematopoietic stem cells on biocompatible nanofiber scaffolds. materials and methods cd133+ hematopoietic stem cells were separated from umbilical cord blood using midimacs (positive selection) system by means of monocolonal antibody cd133 (microbeads) subsequently, flowcytometry method was done to assess the pur...
Background: Colorectal cancer (CRC) is attributed as one of the most common malignancies worldwide. CD133 molecule, as a pentaspan transmembrane glycoprotein, confers stem cell-related characteristics, including self-renewal and multi-directional differentiation capability. CD133 plays important roles in the progression of CRC by conferring apoptotic resistance and migration ab...
Background The aim of this study was the ex vivo expansion of Umbilical Cord Blood hematopoietic stem cells on biocompatible nanofiber scaffolds. Materials and Methods CD133+ hematopoietic stem cells were separated from umbilical cord blood using MidiMacs (positive selection) system by means of monocolonal antibody CD133 (microbeads) subsequently, flowcytometry method was done to asses...
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