Oxidizing agents play a major role in the pathogenesis of liver diseases. Pistacia vera (P. vera), contains many antioxidant substances including coenzyme 10, vitamin E and beta-carotene. The current study was designed to evaluate the probable effects of P. vera on carbon tetrachloride (CCl4)-induced hepatotoxicity in male rats. Frothy male Wistar rats were randomly divided into five groups inc...

the protective effect of liquorice plant extract (lpe) on ccl4-induced hepatotoxicity in common carp was evaluated using fifty adult carps. the fish were cultured in a standard environment in terms of water flow rate, oxygen, ph, food and temperature. the fish were assigned into 5 groups (n = 10) as control, sham, and tests. the test groups were pre-treated for 3 h with various concentrations o...

PURPOSE To study the protective effects and underlying molecular mechanisms of SAMC on carbon tetrachloride (CCl4)-induced acute hepatotoxicity in the mouse model. METHODS Mice were intraperitoneally injected with CCl4 (50 μl/kg; single dose) to induce acute hepatotoxicity with or without a 2-h pre-treatment of SAMC intraperitoneal injection (200 mg/kg; single dose). After 8 h, the blood seru...

The present paper examines the susceptibility to chlordecone (Kepone, CD) and carbon tetrachloride across different ages (35, 45, and 63-days-old) in male and female Sprague-Dawley rats using different lengths of time on a CD diet (10 ppm). The principal findings are that the hepatotoxicity and mortality associated with CD-CCl4 interaction is highly age-dependent for both sexes. There was marke...

Carbon tetrachloride (CCl4) is widely used as an animal model of hepatotoxicity and the mechanisms have been arduously studied, however, the contribution of the sympathetic nervous system (SNS) in CCl4-induced acute hepatotoxicity remains controversial. It is also known that either CCl4 or SNS can affect systemic inflammatory responses. The aim of this study was to establish the effect of chemi...

The role of Nigella Sativa (NS) was investigated in the prevention of carbon tetrachloride (CCl4) induced liver fibrosis. Twenty seven adult wistar-albino rats were allocated into three groups (control, CCl4-induced hepatotoxicity and hepatotoxicity and NS-treated) and after the treatment, rats were sacrified, blood samples were collected for determination of plasma aminotransferases, malondial...

the effects of different concentrations of the hydroalcoholic extract of dried powdered leaves of cichorium intybus l., on ccl4-induced hepatotoxicity in vivo in rats and ccl4-induced cytotoxicity in isolated rat hepatocytes were investigated. rats received different concentrations of the extract by i.p. injection for 3 consecutive days before the injection of (3ml/kg) ccl4 (i.p.). twenty four ...

Oral administration of Liv-52 and kumaryasava to carbon tetrachloride (CCl4) treated rats improved growth. Kumaryasava was more effective in reducing the liver weight increase due to hepatotoxicity of CCl4. Hepatic arginase, cathepsin-B, acid phosphatase, ribonuclease activity which were decreased on CCl4 treatment was stimulated by both Liv-52 and kumaryasava. Results indicate that Liv-52 and ...

The present study was undertaken to evaluate the effect of aminoguanidine (AG) on carbon tetrachloride (CCl4)-induced hepatotoxicity. Treatment of mice with CCl4 (20 microl/kg, i.p.) resulted in damage to centrilobular regions of the liver, increase in serum aminotransferase and rise in lipid peroxides level 24 hours after CCl4 administration. Pretreatment of mice with AG (50 mg/kg, i.p.) 30 mi...